Interaction between left ventricular twist mechanics and arterial haemodynamics during localised, non-metabolic hyperaemia with and without blood flow restriction

Experimental Physiology
Anke Ccm van MilEric J Stöhr

Abstract

What is the central question of this study? Left ventricular (LV) twist is reduced when afterload is increased, but the meaning of this specific heart muscle response and its impact on cardiac output are not well understood. What is the main finding and its importance? This study shows that LV twist responds even when arterial haemodynamics are altered only locally, and without apparent change in metabolic (i.e. heat-induced) demand. The concurrent decline in cardiac output and LV twist during partial arterial occlusion despite the increased peripheral demand caused by heat stress suggests that LV twist may be involved in the protective sensing of heart muscle stress that can override the provision of the required cardiac output. Whether left ventricular (LV) twist and untwisting rate (LV twist mechanics) respond to localised, peripheral, non-metabolic changes in arterial haemodynamics within an individual's normal afterload range is presently unknown. Furthermore, previous studies indicate that LV twist mechanics may override the provision of cardiac output, but this hypothesis has not been examined purposefully. Therefore, we acutely altered local peripheral arterial haemodynamics in 11 healthy humans (women/men n = 3/8; age ...Continue Reading

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Citations

Oct 8, 2017·Experimental Physiology·Jason S AuMaureen J MacDonald
Jan 9, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jason S AuEric J Stöhr
May 31, 2019·Heart·Eric J StöhrJohn R Cockcroft
Jul 13, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Eric J StöhrRory B Weiner
Apr 13, 2018·Frontiers in Physiology·Tsubasa TomotoShigehiko Ogoh
Dec 7, 2016·European Journal of Applied Physiology·Alexander BeaumontJoanna Richards
Sep 16, 2017·Medicine and Science in Sports and Exercise·Eric J StöhrJoseph I Esformes

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