Interaction between lichen secondary metabolites and antibiotics against clinical isolates methicillin-resistant Staphylococcus aureus strains

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Pierangelo BellioGiuseppe Celenza

Abstract

The in vitro antimicrobial activities of five compounds isolated from lichens, collected in several Southern regions of Chile (including the Chilean Antarctic Territory), were evaluated alone and in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus. MIC90, MIC50, as well as MBC90 and MBC50, for the lichen compounds were evaluated. The MIC90 was ranging from 32 µg/ml for perlatolic acid to 128 µg/ml for α-collatolic acid. MBC90 was ranging from onefold up to twofold the MIC90 for each compound. A synergistic action was observed in combination with gentamicin, whilst antagonism was observed for some lichen compounds in combination with levofloxacin. All combinations with erythromycin were indifferent, whilst variability was observed for clindamycin and oxacillin combinations. Data from checkerboard assay were analysed and interpreted using the fractional inhibitory concentration index and the response surface approach using the ΔE model. Discrepancies were found between both methods for some combinations. These could mainly be explained by the failure of FIC approach, being too much subjective and sen...Continue Reading

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Citations

Jan 7, 2016·Frontiers in Molecular Biosciences·Helen A VrionisRaymond J Turner
Jun 1, 2017·Natural Product Reports·Navid AdnaniTim S Bugni
Feb 13, 2019·International Forum of Allergy & Rhinology·Lisa Mary CherianAlkis James Psaltis
Jan 22, 2019·Journal of Applied Microbiology·Ł FurmanekM R D Seaward
May 26, 2021·Planta medica·Isabel Ureña-VacasM Pilar Gómez-Serranillos
Jan 20, 2018·ACS Medicinal Chemistry Letters·Francesca SpyrakisDonatella Tondi
May 19, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pierangelo BellioGiuseppe Celenza

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