Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study

Journal of Hypertension
Arrigo F G CiceroBrisighella Heart Study Group

Abstract

Previous evidence suggest that high low-density lipoprotein cholesterol (LDL-C) and serum uric acid (SUA) levels are risk factors for endothelial dysfunction and vascular ageing. The aim of our study was to evaluate the short-term interaction between SUA, LDL-C and incident hypertension in a sample of overall healthy individuals. In January 2018, we selected from the general database of the Brisighella Heart Study four groups of age and sex-matched nonhypertensive individuals with different levels of LDL-C and SUA level and examined during the 2008 population survey. Incident hypertension has been defined as the increase of SBP values over 140 mmHg and/or of DBP over 90 mmHg and or the beginning of an antihypertensive treatment. In a model adjusted for age, sex, baseline blood pressure, family history of hypertension, smoking status, BMI and physical activity intensity, hazard rations for hypertension development compared with individuals with baseline normal LDL-C and SUA levels are 1.14 [95% confidence interval (95% CI) 0.87-1.55] for individuals with isolated high LDL-C level, 1.55 (95% CI 0.96-2.48) for individuals with isolated high SUA level and 1.57 (95% CI 1.20-2.15) for individuals with both high SUA and LDL-C levels. ...Continue Reading

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Citations

Jan 28, 2021·Journal of Clinical Medicine·Federica PianiClaudio Borghi
Apr 23, 2020·Journal of Population Therapeutics and Clinical Pharmacology Journal De La Thérapeutique Des Populations Et De La Pharamcologie Clinique·Dimitrios GiakoumettisMarios S Themistocleous
Feb 12, 2021·Journal of Clinical Medicine·Pierangelo Coppola On Behalf Of The Brisighella Heart Study Group
Feb 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Woohyeun KimEung Ju Kim
Feb 2, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yeqing GuKaijun Niu
Jan 28, 2020·Nutrition Research Reviews·Mark Tomás Mc Auley
May 21, 2020·Angiology·Agata Bielecka-DabrowaMaciej Banach
Jun 17, 2021·Arquivos brasileiros de cardiologia·Lijun ZhuYingshui Yao
Apr 22, 2021·Panminerva Medica·Federica PianiUNKNOWN Brisighella Heart Study Group

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