Abstract
Previous evidence suggest that high low-density lipoprotein cholesterol (LDL-C) and serum uric acid (SUA) levels are risk factors for endothelial dysfunction and vascular ageing. The aim of our study was to evaluate the short-term interaction between SUA, LDL-C and incident hypertension in a sample of overall healthy individuals. In January 2018, we selected from the general database of the Brisighella Heart Study four groups of age and sex-matched nonhypertensive individuals with different levels of LDL-C and SUA level and examined during the 2008 population survey. Incident hypertension has been defined as the increase of SBP values over 140 mmHg and/or of DBP over 90 mmHg and or the beginning of an antihypertensive treatment. In a model adjusted for age, sex, baseline blood pressure, family history of hypertension, smoking status, BMI and physical activity intensity, hazard rations for hypertension development compared with individuals with baseline normal LDL-C and SUA levels are 1.14 [95% confidence interval (95% CI) 0.87-1.55] for individuals with isolated high LDL-C level, 1.55 (95% CI 0.96-2.48) for individuals with isolated high SUA level and 1.57 (95% CI 1.20-2.15) for individuals with both high SUA and LDL-C levels. ...Continue Reading
References
Oct 21, 2005·International Journal of Clinical Practice·D ErdoganH Muderrisoglu
Jan 15, 2008·Journal of Hypertension·Dalila B CorryMichael L Tuck
Mar 20, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe LippiGiovanni Targher
Jan 29, 2013·The American Journal of Cardiology·Shaye KivityDavid Olchovsky
Dec 7, 2013·Journal of Hypertension·Arrigo F G CiceroUNKNOWN Brisighella Heart Study group
Jan 28, 2014·Annals of Medicine·Claudio BorghiLuca Degli Esposti
Jan 12, 2016·Inflammopharmacology·Mohammed S ElluluFaisal Ali
May 26, 2016·European Heart Journal·Massimo F PiepoliUNKNOWN ESC Scientific Document Group
Aug 9, 2016·Annals of Medicine·Arrigo F G CiceroUNKNOWN Brisighella Heart Study Group
Aug 25, 2016·European Journal of Internal Medicine·Federica FogacciUNKNOWN Brisighella Heart Study Group
Oct 18, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C BorghiA F Cicero
Apr 10, 2017·Atherosclerosis·Federica FogacciUNKNOWN Brisighella Heart Study Group
Apr 12, 2017·Hypertension·Claudio Borghi, Arrigo Francesco Giuseppe Cicero
Sep 21, 2017·Biomedical Reports·Haitao Zhen, Fen Gui
Nov 18, 2017·Journal of the American College of Cardiology·Paul K WheltonJackson T Wright
Mar 20, 2018·International Journal of Cardiology·Masanari KuwabaraMiguel A Lanaspa
May 11, 2018·Journal of Hypertension·Yasuo KansuiTakanari Kitazono
Citations
Jun 15, 2020·International Journal of Cardiology·Mohsen MazidiMaciej Banach
May 18, 2019·Nutrients·Justyna Widomska, Witold K Subczynski
Nov 6, 2020·Inflammation·Yajing Diao
Jan 28, 2021·Journal of Clinical Medicine·Federica PianiClaudio Borghi
Apr 23, 2020·Journal of Population Therapeutics and Clinical Pharmacology Journal De La Thérapeutique Des Populations Et De La Pharamcologie Clinique·Dimitrios GiakoumettisMarios S Themistocleous
Feb 12, 2021·Journal of Clinical Medicine·Pierangelo Coppola On Behalf Of The Brisighella Heart Study Group
Feb 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Woohyeun KimEung Ju Kim
May 28, 2019·Postgraduate Medicine·Wenrui ShiShuang Liu
Feb 2, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yeqing GuKaijun Niu
May 14, 2020·Journal of Hypertension·Eun Sun YuByung Chul Chun
Feb 15, 2020·PloS One·Minkook SonSung Yang
Jan 28, 2020·Nutrition Research Reviews·Mark Tomás Mc Auley
May 21, 2020·Angiology·Agata Bielecka-DabrowaMaciej Banach
May 28, 2020·Scientific Reports·Gang HuangJing Wu
Jun 19, 2019·Nutrients·Berenice Rivera-ParedezRafael Velázquez-Cruz
Jun 20, 2019·Journal of Translational Medicine·Zhi CaoYaogang Wang
Nov 7, 2019·Nutrients·Arrigo F G CiceroClaudio Borghi
Jun 9, 2020·Lipids in Health and Disease·Liliana FonsecaIsabel Palma
Jul 6, 2019·Lipids in Health and Disease·Lei ZhangYuquan Lu
Jul 31, 2019·Journal of Diabetes Research·Guanqun ChaoLizheng Fang
Dec 11, 2019·International Journal of Molecular Sciences·Hui CaoDingzhu Shen
Jun 17, 2021·Arquivos brasileiros de cardiologia·Lijun ZhuYingshui Yao
Jul 30, 2021·International Journal of General Medicine·Junpei LiXiaoshu Cheng
Apr 22, 2021·Panminerva Medica·Federica PianiUNKNOWN Brisighella Heart Study Group