Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns

Neuroscience Letters
Marika S SaarelaK M Mattila

Abstract

Polymorphisms affecting the expression of matrix metalloproteinases (MMPs), i.e. proteolytic enzymes that degrade intercellular material, have been found at position -1607 (1G/2G) in MMP1 and at -1171 (5A/6A) in MMP3. Interestingly, elevated levels of MMP1 and MMP3 have been observed in the brains of Alzheimer's disease (AD) patients and those of tissue inhibitors of MMPs in the cerebrospinal fluid of AD and Parkinson's disease (PD) patients, suggesting a role for MMPs in these disorders. The aim was to investigate a possible association between the afore-mentioned MMP1 and MMP3 polymorphisms and the risk of developing AD or PD. The polymorphisms were genotyped in 97 AD, 52 PD and 101 control patients. We found an interaction between MMP3*5A and APOE 4 alleles (P < 0.0001) which increases the risk of AD (OR: 23.7, 95% CI: 5.8-144.9, P < 0.0001) compared to those who possess neither MMP3*5A nor APOE 4. In conclusion, our finding suggests that the MMP3 gene, especially together with APOE 4, may contribute to the development of AD.

References

Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E SchmechelA D Roses
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·L DunleaveyS Ye
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A GnassoC Cortese
Sep 14, 2000·Neuroscience Letters·A LeakeJ Whateley

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Citations

Jun 22, 2010·International Psychogeriatrics·Solveig HorstmannSimone Wagner
Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea FlexRoberto Pola
Mar 27, 2007·Cephalalgia : an International Journal of Headache·I KaraH Tireli
Sep 9, 2011·Neuromolecular Medicine·Zhiyou CaiAnna Ratka
Nov 6, 2015·Mediators of Inflammation·Marjana BrkicRoosmarijn E Vandenbroucke
Nov 11, 2005·The EMBO Journal·Lesley J PageWilliam E Balch
Sep 19, 2018·Expert Opinion on Therapeutic Targets·Radhika SharmaAnurag Kuhad
Nov 4, 2010·Journal of Neurochemistry·Eun-Mee Kim, Onyou Hwang
May 15, 2021·Mediators of Inflammation·Vladimira DurmanovaIvana Shawkatova

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