Interaction between Methylation and CpG Single-Nucleotide Polymorphisms in the HTR2A Gene: Association Analysis with Suicide Attempt in Schizophrenia

Neuropsychobiology
Ali Bani-FatemiVincenzo De Luca

Abstract

Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes have provided inconsistent findings regarding their role in suicidal behavior. The goal of the current study was to identify single-nucleotide polymorphisms (SNP) within HTR2A that directly affect CpG methylation sites in schizophrenic patients with suicidal behavior. Furthermore, direct methylation analysis was performed using genomic DNA from peripheral leukocytes employing bisulfite pyrosequencing to assess the contributions of six CpG sites in HTR2A exon I in 67 schizophrenia patients assessed for lifetime suicide attempt. Potential methylation in 25 CpG SNPs across the entire HTR2A gene was analyzed considering their direct contribution to methylation. When we compared direct methylation between attempters and nonattempters, we found that only the polymorphic T102C (rs6313) was significantly different between the two groups (p = 0.02). Furthermore, in the potential methylation analysis, we found a nominal association with suicide attempt for six of the 25 SNPs analyzed, i.e. rs2770293 (p = 0.045), rs6313 (p = 0.033), rs17068986 (p = ...Continue Reading

Citations

Oct 27, 2017·Psychiatric Genetics·Ali Bani-FatemiVincenzo de Luca
Jul 15, 2020·Journal of Neural Transmission·Ali Bani-FatemiVincenzo De Luca
Sep 25, 2020·PloS One·Paulina MisztakMagdalena Sowa-Kućma
Nov 2, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Karin HrovatinVita Dolžan
Feb 25, 2020·Journal of Affective Disorders·Serina CheungClement C Zai
Aug 20, 2021·Psychiatric Genetics·Daniel F Ramos-RosalesMarcelo Barraza-Salas

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