Interaction between neural stem cells and bone marrow derived-mesenchymal stem cells during differentiation

Biomedical Reports
J U RongFeng Zhichun

Abstract

Due to their capacity to self-replicate or produce specific differentiated cell types, neural stem cells (NSCs) and bone marrow derived-mesenchymal stem cells (BMSCs) are potential sources for cell transplantation therapies, particularly for neural injury. However, the interaction between NSCs and BMSCs during differentiation has not yet been defined. The interaction is believed to improve the effectiveness and efficiency of cell therapy. In the present study, human NSCs and BMSCs were cultured and the Transwell co-culture system was used to observe the interplay between NSCs and BMSCs during differentiation. The results revealed that NSCs promoted BMSCs to differentiate into neurons and NSCs; whereas, BMSCs did not affect the differentiation of NSCs. Simultaneously, co-culture increased the concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are secreted by NSCs and BMSCs. The present findings suggest that co-culture of NSCs and BMSCs can promote the differentiation and this process may be modulated by BDNF and NGF.

References

Aug 1, 2000·Experimental Neurology·J Sanchez-RamosP R Sanberg
Aug 10, 2000·Journal of Neuroscience Research·D WoodburyI B Black
Nov 2, 2001·Nature·S Temple
May 3, 2002·Nature·Hongjun SongFred H Gage
Aug 12, 2004·Journal of Cell Science·Andreas HermannAlexander Storch
Mar 18, 2005·Cancer Science·Hirofumi HamadaYoshiro Niitsu
Nov 12, 2005·Stem Cells·Wael KafienahAnthony P Hollander
Sep 19, 2006·Stem Cells and Development·Nagwa S El-BadriPaul R Sanberg
Nov 7, 2007·In Vitro Cellular & Developmental Biology. Animal·WeiWei LinXiaoSong Gu
Nov 22, 2007·Journal of Neuroscience Research·Masaaki HokariYoshinobu Iwasaki
Jan 10, 2008·Cell Proliferation·D C Hess, C V Borlongan
Sep 26, 2013·Biochemical and Biophysical Research Communications·Shahnaz RazaviFatemeh Sadat Mostafavi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.