PMID: 26885119Feb 18, 2016Paper

Interaction between peroxisome proliferator- activated receptor gamma polymorphism and overweight on diabetic retinopathy in a Chinese case-control study

International Journal of Clinical and Experimental Medicine
Yan WangRuo-Xi Li

Abstract

Peroxisome proliferator-activated receptors γ (PPAR γ) and overweight were both associated with diabetic retinopathy (DR), so the aim of this study was to investigate the association of four single nucleotide polymorphisms (SNPs) of PPAR γ with DR and additional role of gene-BMI interaction. A total of 500 patients with T2DM (236 men, 264 women), with a mean age of 54.3 ± 15.8 years old, were selected, including 247 diabetic retinopathy patients and 253 controls. Four SNPs were selected for genotyping in the case-control study: rs1805192, rs709158, rs3856806, rs4684847. Logistic regression model was used to examine the interaction between SNP and overweight on DR, odds ratio (OR) and 95% confident interval (95% CI) were calculated. The carriers of C allele of the rs1805192 polymorphism revealed decreased DR risk than those with Pro/Pro variants (Pro/Ala+Ala/Ala versus Pro/Pro, adjusted OR (95% CI)=0.86 (0.65-0.96), P=0.012), after adjusting for covariates. We also found that obese subjects with Pro/Ala or Ala/Ala variants genotype have lowest DR risk, compared to obese subjects with Pro/Pro genotype or non- obese subjects with Pro/Ala or Ala/Ala (OR=0.40, 95% CI=0.32-0.63), after covariates adjustment. Our results support an im...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.