PMID: 8958787Nov 1, 1996Paper

Interaction between prolactin and catecholamines on hypothalamic GnRH release in vitro

The Journal of Endocrinology
A E CalogeroR D'Agata

Abstract

Brain catecholamines have been implicated in the regulation of gonadotrophin release. It has been recently reported that noradrenaline (NA), applied within the hypothalamic paraventricular nucleus, suppresses the pulsatile release of LH in the rat through a corticotrophin-releasing hormone (CRH)-dependent mechanism. Prolactin (PRL) is also able to suppress hypothalamic GnRH release following activation of the CRH-releasing neurone. Given that PRL stimulates the release of NA from hypothalamic explants and that NA stimulates the release of hypothalamic CRH, we hypothesized that this neurotransmitter may be involved in the intrahypothalamic neuroendocrine circuit mediating the inhibitory effects of PRL on GnRH release. To test this hypothesis, we evaluated the effects of PRL on GnRH release in the presence of alpha- or beta-adrenergic receptor antagonists using a static hypothalamic organ culture system which enabled us to evaluate immunoreactive GnRH (iGnRH) release from individually incubated, longitudinally halved hypothalami. As previously shown, PRL at a concentration of 100 nM inhibited basal iGnRH release by about 35%. Phentolamine, a non-selective alpha-adrenergic receptor antagonist, prazosin, an alpha 1-receptor antagon...Continue Reading

Citations

May 21, 2005·Alcohol·Vanessa JimenezAna I Esquifino
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Jul 21, 1998·Annals of the New York Academy of Sciences·A E CalogeroR D'Agata
Mar 30, 2010·Reproduction in Domestic Animals = Zuchthygiene·A P HermanD Tomaszewska-Zaremba
Apr 7, 2004·The European Journal of Neuroscience·Luz TornerInga D Neumann

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