PMID: 8944825Nov 1, 1996Paper

Interaction between prostacyclin and nitric oxide in the reflex control of the coronary circulation in conscious dogs

Cardiovascular Research
G ZhaoT H Hintze

Abstract

Our goal was to determine the role of nitric oxide (NO) on the coronary vasodilation induced by prostacyclin (PGI2) in conscious dogs. Dogs were chronically instrumented for the measurements of coronary blood flow (CBF), left ventricular pressure (LVP), mean arterial pressure (MAP) and heart rate (HR). Intravenous injections of PGI2 caused dose-dependent increases in CBF, and decreases in MAP and late diastolic coronary resistance (LDCR). For instance, CBF increased by 128 +/- 19% (P < 0.05) from 30 +/- 3.5 ml/min and LDCR decreased by 73 +/- 3% (P < 0.05) from 2.57 +/- 0.20 mmHg/ml/min following injection of PGI2 (1.0 microgram/kg). After infusion of nitro-L-arginine (NLA, 35 mg/kg) intravenously, the coronary vasodilation induced by PGI2 was partially attenuated. PGI2 (1.0 microgram/kg) increased CBF by 55 +/- 15% from 33 +/- 5.3 ml/min and decreased LDCR by 42 +/- 9% (both P < 0.05, compared with before NLA) from 3.29 +/- 0.39 mmHg/ml/min. Infusion of L-arginine (100 mg/kg) reversed the action of NLA. For example, PGI2 (1.0 microgram/kg) increased CBF by 115 +/- 15% from 36 +/- 6 ml/min and decreased LDCR by 68 +/- 3% from 3.02 +/- 0.36 mmHg/ml/min (both P > 0.05, compared with before NLA). Atropine (0.1 mg/kg) partially att...Continue Reading

Citations

Apr 27, 1999·British Journal of Pharmacology·E Raczka, A Quintana
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Pooneh BagherSteven S Segal
Nov 26, 2008·European Journal of Pharmacology·Zhiyu TangShiqi Peng
Sep 21, 2016·Journal of Ethnopharmacology·G BrusottiP Kamtchouing
May 19, 2001·Vascular Medicine·K A Dora

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