PMID: 7030976Aug 1, 1981Paper

Interaction between proxyphylline and salbutamol

International Journal of Clinical Pharmacology, Therapy, and Toxicology
J KantoE Tala

Abstract

Salbutamol increased significantly the bronchodilating effect of proxyphylline both in experimental animals and in asthmatic patients. In guinea pigs (modified Konzett-Rössler method) the reduction in response to metacholine caused by increasing doses of proxyphylline and salbutamol significantly exceeded that of either drug alone. In a double-blind, randomized cross-over study conducted on 3 consecutive days, asthmatic patients received 500 mg proxyphylline orally three times daily. On the 2nd or 3rd day a significantly greater improvement in the peak expiratory flow was found after the combination of proxyphylline and salbutamol (3 mg p.o.) in comparison with proxyphylline and placebo. Salbutamol had no significant effect on the plasma concentrations of proxyphylline, which varied between 14 and 22 microgram/ml. The combination of oral proxyphylline and salbutamol is clinically useful in increasing drug response without increased adverse effects.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.