Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response

Progress in Neuro-psychopharmacology & Biological Psychiatry
Ricard NavinésCristóbal Gastó

Abstract

Interactions between serotonergic and the endogenous opioid systems have been suggested to be involved in the etiopathogenesis of depression and in the mechanism of action of antidepressants. Activation of serotonin 5-HT1A receptors has been shown to increase plasma beta-endorphin (beta-END) levels in animal studies and in healthy humans. To assess interaction abnormalities between 5-HT1A receptors and the endogenous opioid system in patients with major depression and the possible modulating effect of citalopram. The beta-END response to the 5-HT1A receptor agonist, buspirone (30 mg), was measured in 30 patients with major depression and in 30 age- and sex-matched healthy controls before and after an 8-week treatment with citalopram. Pre-treatment score of the Hamilton Rating Scale for Depression (HRSD) was >or=17. Antidepressant response was defined by a 50% decrease in the HRSD. Pre- and post-treatment maximum peak response (Deltamax) and the area under the curve (AUC) of beta-END response were compared. Three time points were measured (60, 90 and 120 min). We also examined the correlations between the beta-END response and the antidepressant response. Buspirone plasma levels were not measured. At baseline, beta-END response ...Continue Reading

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Jun 15, 2007·Human Psychopharmacology·Ricard NavinésCristóbal Gastó

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Citations

Nov 16, 2010·Irish Journal of Medical Science·P C DinasA D Flouris
Sep 29, 2009·Archives of Pharmacal Research·Ozgür Devrim CanYusuf Oztürk
Jan 7, 2010·Journal of Affective Disorders·Ilona S YimCurt A Sandman
Sep 1, 2019·International Journal of Psychiatry in Medicine·Paul A Zarkowski
Feb 24, 2015·Medicine and Science in Sports and Exercise·Jay R HoffmanHagit Cohen
Mar 13, 2020·Frontiers in Psychology·Michael Kirsch, Michael B Buchholz
Oct 2, 2009·Peptides·Richard J Bodnar

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