PMID: 3768381Oct 24, 1986Paper

Interaction between the 35 kDa apolipoprotein of pulmonary surfactant and saturated phosphatidylcholines. Effects of temperature

Biochimica Et Biophysica Acta
R J KingS C Dang

Abstract

We studied the interaction between the 35 kDa apolipoprotein of canine pulmonary surfactant (SP 35) and five saturated phosphatidylcholines: distearoyl (DSPC), diheptadecanoyl (DHPC), dipalmitoyl (DPPC), dimyristoyl (DMPC), and dilauroyl (DLPC); and two monoenoic unsaturated phosphatidylcholines: dioleoyl (DOPC) and dielaidyl (DEPC), using temperatures at which all of the phospholipids except DOPC were in both the gel and liquid-crystalline states. The experiments were carried out in a buffer without Ca2+. The amount of apolipoprotein which was bound by both small unilamellar and multilayered vesicles of these lipids decreased as the temperature was increased. Moreover, near the temperatures of the phase transitions of all lipids except DLPC, there was an abrupt and marked reduction in binding of protein, in that over a 3-4 degree change in temperature there was an abrupt decrease in bound apolipoprotein. A similar change in binding occurred using DLPC, although the relatively large changes in bound protein occurred at about 10 and 20 degrees C, temperatures which are above the phase transition temperature of this lipid. Experiments using DOPC were limited to temperatures above the phase transition, and apolipoprotein binding w...Continue Reading

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Citations

Jan 1, 1988·General Pharmacology·T E Weaver
Jun 23, 1998·Biophysical Journal·K NagK M Keough
Feb 22, 2001·Annual Review of Physiology·S Hawgood, F R Poulain
Jun 1, 1992·The American Review of Respiratory Disease·R HiguchiM Ikegami
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Jul 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chia-Lang FangJia-You Fang
Mar 19, 2004·The Journal of Biological Chemistry·Brigitte NuscherKlaus Beyer
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Jul 17, 1998·Biochimica Et Biophysica Acta·R Koynova, M Caffrey
Mar 23, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ryan W LoneyStephen B Hall

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