Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness

The European Respiratory Journal
Marie-Hélène DizierF Demenais

Abstract

A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families, performed in the presence of a gene×early-life environmental tobacco smoke (ETS) exposure interaction, showed the strongest interaction in the 17p11 region where linkage was detected only among unexposed siblings. Our goal was to conduct fine-scale mapping of 17p11 to identify single nucleotide polymorphisms (SNPs) interacting with ETS that influence BHR.Analyses were performed in 388 French EGEA asthmatic families, using a two-step strategy: 1) selection of SNPs displaying family-based association test (FBAT) association signals (p≤0.01) with BHR in unexposed siblings, and 2) a FBAT homogeneity test between exposed and unexposed siblings plus a robust log-linear interaction test.A single SNP reached the threshold (p≤3×10(-3)) for significant interaction with ETS using both interaction tests, after accounting for multiple testing. Results were replicated in 253 French-Canadian families, but not in 341 UK families, probably due in part to differences in phenotypic features between datasets.The SNP showing significant interaction with ETS belongs toDNAH9(dynein, ...Continue Reading

References

Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·J H SissonS I Rennard
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·R I EhrlichE Weinberg
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·F KauffmannJ Feingold
Jan 13, 2000·American Journal of Human Genetics·D M Umbach, C R Weinberg
Nov 4, 2000·American Journal of Human Genetics·S L LakeN M Laird
Feb 15, 2001·European Journal of Human Genetics : EJHG·A K MaitiP Bouvagnet
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·Z WangX Xu
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Susan ColillaUNKNOWN Collaborative Study for the Genetics of Asthma
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Deborah A MeyersEugene R Bleecker
Jan 18, 2008·Genetic Epidemiology·Charles Kooperberg, Michael Leblanc
Oct 17, 2008·The New England Journal of Medicine·Emmanuelle BouzigonFlorence Demenais
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Gerard H KoppelmanDirkje S Postma
Jan 1, 2010·American Journal of Respiratory Cell and Molecular Biology·Samantha M SimetTodd A Wyatt
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Jul 15, 2011·The Journal of Allergy and Clinical Immunology·Chang XiaoDonna E Davies
Dec 12, 2012·Current Opinion in Allergy and Clinical Immunology·Matthias WjstMatthias Arnold
Jan 22, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Blazenka Kljaic BukvicAdnan Custovic
Apr 30, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mario BlekicAngela Simpson
Jul 12, 2013·Human Molecular Genetics·Lauren J Buro-AuriemmaRonald G Crystal
Jul 25, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jiakai WuAngela Simpson
Sep 6, 2013·European Journal of Epidemiology·Markus J Ege, David P Strachan
Nov 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sandra K GilleyP Darwin Bell
Dec 10, 2013·The Journal of Allergy and Clinical Immunology·Salome ScholtensH Marike Boezen
Feb 25, 2014·The Journal of Allergy and Clinical Immunology·Marie-Hélène DizierFlorence Demenais
Oct 23, 2014·American Journal of Respiratory and Critical Care Medicine·Brian D ModenaSally E Wenzel
Nov 13, 2014·Médecine sciences : M/S·Ruxandra Bachmann-Gagescu
Nov 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BouzigonUNKNOWN Early Genetics Lifecourse Epidemiology (EAGLE) Consortium

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Citations

Apr 11, 2018·International Archives of Allergy and Immunology·Yang PengDe-Yun Wang
Aug 6, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Pierre-Emmanuel SugierEmmanuelle Bouzigon
Jul 27, 2018·Current Allergy and Asthma Reports·Wei-Jie GuanDe Yun Wang
Jan 17, 2021·Human Genome Variation·Kazuhiko TakeuchiTakao Fujisawa
Jan 1, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Elisabet JohanssonJocelyn M Biagini

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