Interaction between the gut microbiome and mucosal immune system

Military Medical Research
Na ShiHaitao Niu

Abstract

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.

References

Jan 1, 1968·International Archives of Allergy and Applied Immunology·P A CrabbéJ F Heremans
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A T GewirtzJ L Madara
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·F SierroJ C Sirard
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monisha G ScottRobert E W Hancock
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heuy-Ching WangJohn R Klein
Jan 28, 2003·Nature Immunology·Lora V HooperJeffrey I Gordon
Oct 15, 2003·Arthritis and Rheumatism·Solbritt Rantapää-DahlqvistWalther J van Venrooij
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magali MorettoImtiaz A Khan
Jul 28, 2004·Trends in Microbiology·Tokiyoshi AyabeToru Kono
Mar 22, 2005·Nature Cell Biology·Johan H van EsHans Clevers
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Aug 10, 2006·European Journal of Immunology·Sofia OstmanEsbjörn Telemo
Aug 26, 2006·Science·Heather L CashLora V Hooper
Sep 22, 2006·Journal of Clinical Microbiology·Uri GophnaSander J O Veldhuyzen van Zanten
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jan 9, 2007·Clinical Rheumatology·Taha Rashid, Alan Ebringer
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Feb 7, 2008·Inflammatory Bowel Diseases·Martina E SpehlmannStefan Schreiber
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Dec 23, 2008·Immunity·Lauren A ZenewiczRichard A Flavell
May 16, 2009·Current Pharmaceutical Design·G T MacfarlaneS Macfarlane
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Nov 6, 2009·The New England Journal of Medicine·Erik-Oliver GlockerChristoph Klein
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter BergqvistMats Bemark
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·June L Round, Sarkis K Mazmanian
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yun Kyung LeeSarkis K Mazmanian
Jan 5, 2011·Immunity·Gregory F SonnenbergDavid Artis

❮ Previous
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Citations

Sep 7, 2018·PLoS Pathogens·Meagan E Sullender, Megan T Baldridge
Sep 19, 2018·Expert Review of Proteomics·Huafeng LinEdouard C Nice
Feb 13, 2019·Nutrients·Starin McKeenNicole C Roy
Nov 15, 2019·Current Opinion in Rheumatology·Lacey J FavazzoMichael J Zuscik
Mar 19, 2020·International Journal of Molecular Sciences·Begoña Alburquerque-GonzálezPablo Conesa-Zamora
Nov 17, 2019·Journal of Gastroenterology and Hepatology·Hai-Yin JiangYu-Dan Shi
Mar 22, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tasha BarrIlhem Messaoudi
Aug 20, 2020·Applied Microbiology and Biotechnology·Aravind SundararamanPrakash M Halami
Mar 30, 2018·Frontiers in Microbiology·Maria C OpazoClaudia A Riedel
Jan 27, 2019·Current Gastroenterology Reports·Victoria M Gershuni, Elliot S Friedman
Apr 9, 2020·Clinical and Molecular Allergy : CMA·Khui Hung LeeGuicheng Zhang
Jun 26, 2020·Frontiers in Microbiology·Li-Hong HeLei Zhang
May 23, 2019·Frontiers in Immunology·Felix HaussnerMarkus Huber-Lang
Aug 28, 2019·International Journal of Molecular Sciences·Sally TemrazAli Shamseddine
Dec 15, 2019·Journal of Translational Medicine·Manoj KumarSouhaila Al Khodor
Jan 1, 2020·Journal of Biomedical Semantics·Yongqun HeJihad S Obeid
Feb 19, 2020·Digestive Diseases and Sciences·Md Abdul Wadud KhanJennifer A Wargo
Jul 9, 2020·Frontiers in Medicine·Alice RouanetMagali Cordaillat-Simmons
Aug 5, 2017·Frontiers in Microbiology·Susannah Selber-HnatiwChiara Gamberi
Oct 31, 2018·Scientific Data·Ashok Kumar DubeyAnirban Bhaduri
Jun 4, 2018·Brain : a Journal of Neurology·Carlos R Camara-LemarroyV Wee Yong
Dec 5, 2019·World Journal of Clinical Cases·Hussein SabitHuseyin Tombuloglu
Aug 28, 2019·International Journal of Molecular Sciences·Parisa Gazerani
Sep 19, 2017·Frontiers in Microbiology·Olga N IlinskayaIlgiz G Gataullin
Aug 10, 2018·Mucosal Immunology·Julie ChesnéHenrique Veiga-Fernandes
Mar 7, 2020·International Journal of Molecular Sciences·Pedram HonarpishehBhanu P Ganesh
Aug 11, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Jennifer O AdeghateKatalin Kristóf
May 7, 2019·Frontiers in Nutrition·Ken YoshiiJun Kunisawa
May 20, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Rod A Herman
Mar 3, 2020·Frontiers in Immunology·Rodrigo Jiménez-SaizManel Jordana
Oct 21, 2020·Canadian Journal of Microbiology·Ethendhar RajendiranVanu Ramprasath

❮ Previous
Next ❯

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