PMID: 119594Dec 1, 1979

Interaction between the thyrotrophin-releasing hormone-induced growth hormone rise and dopaminergic drugs: studies in pathologic conditions of the animal and man

Clinical Endocrinology
E E MüllerA E Panerai

Abstract

A rise in plasma growth hormone (GH) after thyrotrophin-releasing hormone (TRH) and a striking reduction after dopaminergic drugs is present in acromegalic ('responder') patients. We have investigated the GH response to dopaminergic stimuli in two conditions of animals and man, which, like acromegaly, are characterized by a TRH-induced GH rise, i.e. rats with electrolytic lesions of the median eminence (ME) and patients with hepatic cirrhosis. In addition, we have studied the TRH-induced GH rise in rats with ME lesions, in the cirrhotic patients and in a group of 'responder' acromegalics before and after administration of dopaminergic drugs. In rats with ME lesions an infusion of dopamine (DA) neither modified baseline GH levels nor the TRH-induced GH rise. In five out of six cirrhotic patients oral administration of L-Dopa was followed by the usual rise in plasma GH. infusion of DA increased plasma GH levels in three out of seven cirrhotic patients and in four out of five subjects an earlier GH rise after TRH was seen. However, in the 'responder' acromegalics, the infusion of DA, besides lowering baseline plasma GH, was capable of reducing the TRH-induced GH rise. Collectively these data indicate that the TRH-induced GH rise e...Continue Reading

References

Dec 13, 1975·Lancet·Y SachdevS K Goolamali
Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·W J LeebawP D Woolf
Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·F CamanniE E Müller
Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A E BoydM Mager
Apr 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·A E PaneraiE E Müller
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·A E PaneraiE E Müller
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·G N BurrowR K Donabedian
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·M IshibashiK Kosaka
May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·B CorenblumC Ezrin
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·K MaedaH Imura
Nov 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G S BessesR K Donabedian
Mar 1, 1977·The Journal of Clinical Endocrinology and Metabolism·F CamanniG M Molinatti
Nov 1, 1977·Life Sciences·Y C Clement-CormierG A Robison
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·F CamanniG M Molinatti
Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·D Gonzalez-BarcenaA V Schally
May 1, 1973·The Journal of Pharmacy and Pharmacology·H CorrodiU Ungerstedt
Dec 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A LiuzziF Silvestrini
Jan 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H ImuraH Matsuyama
Feb 1, 1974·The Journal of Clinical Endocrinology and Metabolism·P G ChiodiniF Silvestrini
Dec 2, 1971·The New England Journal of Medicine·M S AndersonA J Wise
Dec 24, 1970·The New England Journal of Medicine·A E BoydJ B Pfeiffer
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderS Ellis
Jan 1, 1949·Stain Technology·E R HAYES

Citations

Jan 21, 1982·The New England Journal of Medicine·I M Jackson
Mar 1, 1991·Acta Neurologica Scandinavica·G CusimanoG Meco
Dec 24, 1997·Acta Paediatrica. Supplement·I Berczi
Jul 21, 1998·Annals of the New York Academy of Sciences·I Berczi
Dec 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·A Martinez-CamposE E Müller
Feb 1, 1981·Clinical Endocrinology·M LangerL Chiandussi
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi

Related Concepts

Acromegaly
Parlodel
Intropin
Drug Interactions
Levopa
Fibrosis, Liver
Median Eminence of Hypothalamus
Prolactin
Recombinant Growth Hormone
Proterelin Tartrate Hydrate

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
R J Craig
The Journal of Clinical Endocrinology and Metabolism
L Bhandrau, C H Emerson
Alcoholism, Clinical and Experimental Research
O P GandaM L Mitchell
Journal of Neurology, Neurosurgery, and Psychiatry
N F Lawton, J MacDermot
© 2021 Meta ULC. All rights reserved