Interaction between Trichomonas vaginalis and the Prostate Epithelium

The Korean Journal of Parasitology
Jung-Hyun KimJae-Sook Ryu

Abstract

Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T. vaginalis are involved in inflammation of prostate epithelial cells. When RWPE-1 cells were infected with T. vaginalis (1:0.4 or 1:4), adhesion of T. vaginalis continuously increased for 24 hr or 3 hr, respectively. The cytotoxicity of prostate epithelial cells infected with T. vaginalis (RWPE-1: T. vaginalis=1:0.4) increased at 9 hr; at an infection ratio of 1:4, cytotoxicity increased after 3 hr. When the RWPE-1 to T. vaginalis ratio was 1:0.4 or 1:4, production of IL-1β, IL-6, CCL2, and CXCL8 also increased. Epithelial-mesenchymal transition (EMT) was verified by measuring decreased E-cadherin and increased vimentin expression at 24 hr and 48 hr. Taken toge...Continue Reading

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Citations

Jun 13, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael DaughertyTimothy Byler
Aug 14, 2020·International Journal of Environmental Research and Public Health·John F Alderete
Oct 21, 2020·Cancers·Maddison ArcherNatasha Kyprianou
Jun 4, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Olivia T Van GerwenChristina A Muzny

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Methods Mentioned

BETA
ELISA
fluorescence microscopy

Software Mentioned

ImageJ
Las

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