Interaction between TSPO-a neuroimmune marker-and redox status in clinical high risk for psychosis: a PET-MRS study

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Sina HafiziRomina Mizrahi

Abstract

Altered neuroimmune response and oxidative stress have both been implicated in the pathophysiology of schizophrenia. While preclinical studies have proposed several pathways regarding potential interactions between oxidative stress and neuroimmune imbalance in the development of psychosis, the molecular mechanisms underlying this interaction are not yet understood. To date, no study has investigated this link in vivo in the human brain. We conducted the first in vivo study linking translocator protein 18  kDa (TSPO) expression and glutathione (a major brain antioxidant and a marker for redox status) in the medial prefrontal cortex (mPFC) of a relatively large sample of participants (N = 48) including 27 antipsychotic-naïve individuals at clinical high risk for psychosis and 21 matched healthy volunteers using high-resolution PET with TSPO radioligand, [18F]FEPPA, and 3T proton magnetic resonance spectroscopy (1H MRS). The omnibus model (including TSPO genotype as covariate) was significant (F(4, 43) = 10.01, p < 0.001), with a significant group interaction (t = -2.10, p = 0.04), suggesting a different relation between [18F]FEPPA VT and glutathione in each clinical group. In healthy volunteers, but not in individuals at clinical...Continue Reading

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Citations

May 15, 2019·Current Opinion in Neurology·Sabine Hellwig, Katharina Domschke
Jul 1, 2020·Current Behavioral Neuroscience Reports·Maju Mathew KoolaAnilkumar Pillai
Dec 24, 2020·Personality Neuroscience·Cory GerritsenRomina Mizrahi
Mar 10, 2019·Schizophrenia Research·Rebecca Birnbaum, Daniel R Weinberger

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Software Mentioned

XSOS
- Point RESolved Spectroscopy ( MEGA - PRESS )
MEshcher
ROMI
SPSS

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