PMID: 12773074May 30, 2003Paper

Interaction between warfarin and the herbal product quilinggao

The Annals of Pharmacotherapy
Anna L N Wong, Thomas Y K Chan

Abstract

To describe a patient with loss of anticoagulation control and bleeding after consumption of the combination herbal product quilinggao. A 61-year-old man who was stable on warfarin therapy regularly consumed a jelly-like herbal product called quilinggao ("essence of tortoise shell"). Five days after the daily consumption of a second brand of quilinggao, he developed easy gum bleeding, epistaxis, and skin bruising with an international normalized ratio (INR) >6.0. Warfarin therapy was temporarily withdrawn until the INR decreased to 1.9. On the day of hospital discharge, he took a third brand of quilinggao against medical advice. Three days later, his INR was 5.2. Warfarin therapy was again temporarily withheld and the patient counseled about an apparent herb-warfarin interaction. He could not remember the name of the third brand of quilinggao. Quilinggao is a very popular Chinese herbal product. There are many different brands, and the composition of herbal products varies between manufacturers. Chuanbeimu (Fritillaria cirrhosa) in the first brand and beimu (Fritillaria spp.), chishao (Paeoniae rubra, Chinese peony), jinyinhua (Lonicera japonica), and jishi (Poncirus trifoliata) in the second brand of quilinggao have antiplatel...Continue Reading

References

Jun 1, 1992·Thrombosis Research·C M TengT F Huang
Apr 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W C Chang, F L Hsu
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Apr 17, 2001·The Annals of Pharmacotherapy·T Y Chan

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Citations

Jul 12, 2005·Current Treatment Options in Cardiovascular Medicine·Edith A Nutescu, Cathy M Helgason
Jul 21, 2007·The Journal of Laryngology and Otology·F JavedH Sharp
Aug 10, 2012·European Journal of Clinical Pharmacology·Hsin-Hui TsaiTsai-Chung Li
Jan 22, 2005·Fundamental & Clinical Pharmacology·Angelo A Izzo
Mar 24, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jin Gyu ChoiMyung Sook Oh
Sep 30, 2005·Journal of Ethnopharmacology·Hyun-Tai LeeChang-Koo Shim
Apr 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Hsu-Yuan LuChang-Nam Ko
Jun 11, 2016·Journal of Forensic Sciences·Roger W Byard
Feb 3, 2015·Singapore Medical Journal·Yan Ting ChuaKei Siong Khoo
Nov 26, 2009·The American Journal of Chinese Medicine·Kun Shan HuangHsiu-Chung Ou
Jul 14, 2010·The American Journal of Chinese Medicine·Wen-Kuei FangChih-Yang Huang
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joseph Boullata
Jan 25, 2018·British Journal of Clinical Pharmacology·Charles AwortweBernd Rosenkranz
Jun 19, 2007·Human Reproduction Update·Fritz WieserRobert N Taylor
Jun 2, 2020·British Journal of Clinical Pharmacology·Christina San San Tan, Shaun Wen Huey Lee
May 29, 2018·Internal and Emergency Medicine·Giada CrescioliAlfredo Vannacci
Aug 27, 2021·Medicines·Mary Beth BabosPaul Herscu

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