Interaction between X-Delta-2 and Hox genes regulates segmentation and patterning of the anteroposterior axis

Mechanisms of Development
João N PeresAnthony J Durston

Abstract

In vertebrates, the paraxial mesoderm already exhibits a complex Hox gene pattern by the time that segmentation occurs and somites are formed. The anterior boundaries of the Hox genes are always maintained at the same somite number, suggesting coordination between somite formation and Hox expression. To study this interaction, we used morpholinos to knockdown either the somitogenesis gene X-Delta-2 or the complete Hox paralogous group 1 (PG1) in Xenopus laevis. When X-Delta-2 is knocked down, Hox genes from different paralogous groups are downregulated from the beginning of their expression at gastrula stages. This effect is not via the canonical Notch pathway, as it is independent of the Notch effector Su(H). We also reveal for the first time a clear role for Hox genes in somitogenesis, as loss of PG1 gene function results in the perturbation of somite formation and downregulation of the X-Delta-2 expression in the PSM. This effect on X-Delta-2 expression is also observed during neurula stages, before the somites are formed. These results show that somitogenesis and patterning of the anteroposterior axis are closely linked via a feedback loop involving Hox genes and X-Delta-2, suggesting the existence of a coordination mechani...Continue Reading

References

Aug 1, 1991·Current Opinion in Genetics & Development·P Gruss, M Kessel
Jan 1, 1991·Methods in Cell Biology·R M Harland
Nov 1, 1990·Developmental Biology·R Winklbauer
Jan 15, 1997·Developmental Biology·F Chen, M R Capecchi
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Jun 1, 1999·Mechanisms of Development·J C Rusconi, V Corbin
Dec 14, 1999·Current Topics in Developmental Biology·R Keller
Aug 10, 2000·Nature Genetics·Y TakahashiY Saga
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N KishiK Matsuno
May 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S J Gaunt
Nov 1, 2001·Annual Review of Cell and Developmental Biology·O Pourquié
Aug 30, 2002·Current Opinion in Genetics & Development·Alfonso Martinez AriasKeith Brennan
Jan 29, 2003·The Journal of Biological Chemistry·Takeshi Ikeuchi, Sangram S Sisodia
Oct 1, 2003·Mechanisms of Development·Massimiliano AndreazzoliIrma Nardi
Dec 31, 2003·Developmental Biology·Padmashree C G RidaYun Jin Jiang
Jun 3, 2004·Mechanisms of Development·Tomomi Kiyota, Tsutomu Kinoshita
Sep 17, 2005·Genes & Development·Marta CarapuçoMoisés Mallo
Jan 7, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·João N Peres, Antony J Durston

❮ Previous
Next ❯

Citations

Dec 14, 2011·Development, Growth & Differentiation·Lydia MichautWalter J Gehring
Oct 15, 2011·PLoS Computational Biology·Kirsten H Ten Tusscher, Paulien Hogeweg
Nov 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Antony J Durston
Dec 18, 2015·Nature Reviews. Neuroscience·Detlev ArendtHeather Marlow
Nov 28, 2015·Zoological Letters·Takayuki OnaiShigeru Kuratani
Jun 9, 2015·Seminars in Cell & Developmental Biology·A J Durston, K Zhu
May 25, 2015·Seminars in Cell & Developmental Biology·A J Durston
Nov 26, 2015·Zoological Letters·Takayuki OnaiShigeru Kuratani
Apr 26, 2019·Genesis : the Journal of Genetics and Development·Antony J Durston
Feb 15, 2007·Genesis : the Journal of Genetics and Development·Stacy L K RasmussenNicholas D Holland
Dec 19, 2019·Frontiers in Cell and Developmental Biology·Antony J Durston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.