Abstract
Paraoxonase 1 (PON1) plays an important role in reducing the risk of coronary heart disease (CHD). Smoking is known to reduce PON1 activity. We aimed to investigate the effects of interactions between PON1 variants and smoking on CHD in the Singaporean Chinese population. In a case-control study nested within Singapore Chinese Health Study (N=1914), subjects with and without CHD were classified into never-smokers and ever-smokers (ever smoked at least one cigarette a day for 1 year or longer). Associations at four independent SNPs at the PON1 locus (rs3735590, rs3917550, rs662, rs3917481) with CHD were evaluated using logistic regression, before/after stratification on smoking status. Interactions between smoking and PON1 variants were analyzed with likelihood ratio tests, by including the SNP*smoking interaction term in regression analyses. The T allele at the coding SNP, rs662, was associated with higher risk of CHD in ever-smokers only (OR=1.35, 95% CI 1.08-1.68; adjusted P=0.036). At the miR-SNP, rs3735590, carrying at least one copy of minor allele T was associated with increased risk of CHD in a dominant manner in never-smokers only (OR=1.53, 95% CI 1.11-2.11; adjusted P=0.036). Significant interactions between two PON1 S...Continue Reading
References
Jul 29, 1991·FEBS Letters·M I MacknessP N Durrington
Jan 1, 1993·Nature Genetics·R HumbertC E Furlong
Aug 1, 1995·Journal of Cardiovascular Risk·J Cosin-AguilarA Bayes-De-Luna
Dec 1, 1995·The Journal of Clinical Investigation·M Serrato, A J Marian
Apr 1, 1996·Current Opinion in Lipidology·M I MacknessR A Hegele
Oct 25, 1996·Atherosclerosis·S M HerrmannF Cambien
Apr 15, 1997·The Journal of Clinical Investigation·M NavabB N La Du
Mar 22, 1997·Lancet·M I MacknessP N Durrington
Mar 7, 1998·American Journal of Human Genetics·D K SangheraM I Kamboh
Mar 20, 1998·FEBS Letters·B MacknessP N Durrington
Dec 23, 1998·Atherosclerosis·Y L KoY S Lee
Mar 17, 1999·Diabetes·M PfohlH U Häring
May 16, 2000·Circulation·R W JamesA Righetti
Jan 5, 2002·Nutrition and Cancer·J H HankinM C Yu
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
May 29, 2004·Current Opinion in Lipidology·Godfrey S Getz, Catherine A Reardon
Sep 4, 2007·Lancet·A Sonia BuistUNKNOWN BOLD Collaborative Research Group
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Tamali BhattacharyyaStanley L Hazen
Jan 17, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Karen HuenNina Holland
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Sep 23, 2009·Indian Journal of Medical Sciences·S AgrawalS Mastana
Mar 23, 2012·JAMA : the Journal of the American Medical Association·Gaetano Santulli
Mar 19, 2013·Atherosclerosis·Mu-En LiuSuh-Hang H Juo
Citations
Sep 8, 2016·Medicine·Kuibao LiXinchun Yang
Dec 22, 2017·Scientific Reports·Yi HanChew-Kiat Heng
Feb 27, 2018·Nutrition Journal·Xuling ChangChew-Kiat Heng
Nov 20, 2016·Medicine·Yazmín Hernández-DíazJosé Francisco Cámara-Álvarez
Aug 22, 2018·Herz·Z DengW Gao
Jun 29, 2018·Medicine·Zhen ZhangJian Li
Nov 1, 2020·Nutrition Journal·Xuling ChangChew-Kiat Heng
Sep 10, 2020·Journal of Biochemical and Molecular Toxicology·Ayla Solmaz AvcikurtHasmet Yazici
Jan 8, 2021·BMC Cardiovascular Disorders·Hu LiKui Wang
May 5, 2021·Communications Biology·Xuling ChangRajkumar Dorajoo