Interaction networks of hepatitis C virus NS4B: implications for antiviral therapy

Cellular Microbiology
Shanshan LiLingbao Kong

Abstract

Hepatitis C virus (HCV) is an important human pathogen infecting more than 170 million people worldwide with approximately three million new cases each year. HCV depends heavily on interactions between viral proteins and host factors for its survival and propagation. Among HCV viral proteins, the HCV non-structural protein 4B (NS4B) has been shown to mediate virus-host interactions that are essential for HCV replication and pathogenesis and emerged as the target for anti-HCV therapy. Here, we reviewed recent knowledge about the NS4B interaction networks with host factors and its possible regulatory mechanisms, which will both advance our understanding of the role of NS4B in HCV life cycle and illuminate potential viral and host therapeutic targets.

References

Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H Hoofnagle
Jan 13, 2000·Biochemical and Biophysical Research Communications·J S ParkM K Min
Jun 13, 2000·Oncogene·R Jove
Jan 10, 2002·Journal of Medical Virology·Jun KatoMasao Omata
Feb 28, 2002·Journal of Hepatology·Marianna D A GaçaR Christopher Benyon
May 8, 2002·The Journal of Clinical Investigation·Jay D HortonMichael S Brown
Nov 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuFrancis V Chisari
Nov 26, 2002·Biochemical and Biophysical Research Communications·Wen Yan TongHak Hotta
Apr 15, 2003·Journal of Virology·Marika LundinMats A A Persson
Apr 29, 2003·IUBMB Life·Andrew HammetJörg Heierhorst
Sep 29, 2004·Journal of Virology·Shirit EinavJeffrey S Glenn
Dec 18, 2004·Mutation Research·Martin Schröder, Randal J Kaufman
Feb 26, 2005·Seminars in Liver Disease·Patrice AndréVincent Lotteau
Apr 14, 2005·Journal of Biochemistry and Molecular Biology·Yi ZhengZhen-hui Wu
May 30, 2006·Journal of Virology·Guann-Yi YuMichael M C Lai
Oct 13, 2006·The Journal of General Virology·Marika LundinMats A A Persson
Feb 16, 2007·Journal of Virology·Michelle StoneKouacou V Konan
May 10, 2007·Nature Reviews. Microbiology·Darius MoradpourCharles M Rice
May 18, 2007·Journal of Molecular Graphics & Modelling·Christoph WelschStefan Zeuzem
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Feb 6, 2009·International Journal of Cancer. Journal International Du Cancer·Joice Kuroiwa-TrzmielinaFernando Salvador Moreno
May 20, 2009·BMC Medical Genomics·Perry EvansAydin Tozeren
May 27, 2009·Virology Journal·Jolanda M P LiefhebberHans C van Leeuwen
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Jun 1, 2007·Hepatology International·Masaru MoriyamaMasao Omata
Oct 27, 2009·Trends in Endocrinology and Metabolism : TEM·Gulam H SyedAleem Siddiqui
Oct 28, 2009·Biology of the Cell·Costin-Ioan Popescu, Jean Dubuisson
Jan 14, 2010·Reviews in Medical Virology·Jérôme GouttenoireDarius Moradpour
Apr 8, 2010·Science Translational Medicine·Nam-Joon ChoJeffrey S Glenn

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Citations

Jan 23, 2016·Pathogens·Claire D James, Sally Roberts
Aug 30, 2014·Critical Reviews in Microbiology·Shanshan LiXilan Yu
Jun 1, 2016·Biochemical and Biophysical Research Communications·Kittirat Glab-AmpaiWanpen Chaicumpa
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bo HuYi Zheng
Feb 12, 2014·Journal of Medicinal Chemistry·Barton PhillipsCatalin Zonte
Nov 29, 2017·PloS One·Ana Claudia Silva BragaPaula Rahal
Sep 8, 2018·PLoS Computational Biology·Ahmed Abdul QuadeerMatthew R McKay
May 2, 2019·BMC Infectious Diseases·Qurat Ul Ain Farooq, Faisal F Khan
Aug 10, 2021·International Journal of Biological Macromolecules·Zibing YangLingbao Kong

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