PMID: 9427535Jan 14, 1998Paper

Interaction of 11 cisplatin analogues with DNA: characteristic pattern of damage with monofunctional analogues

Biochimica Et Biophysica Acta
V MurrayW David McFadyen

Abstract

In this paper the sequence specificity of DNA damage has been determined for 11 cisplatin analogues. A number of the analogues used in this study have been included in clinical trials. A Taq DNA polymerase linear amplification technique was utilised to ascertain the sequence selectivity of cisplatin analogues damage to DNA. The analogues differed in their ability to damage DNA with cisplatin being the most effective DNA damaging agent followed by (in decreasing order): tetraplatin (tetrachloro(1,2-diaminocyclohexane)platinum(IV) (RR isomer)), cis-dichlorobis(isopropylamine)platinum(II), dichloro(1,2-diaminocyclohexane)platinum(II) (SS isomer), dichloro(1,2-diaminocyclohexane)platinum(II) (RR isomer), cis-bis(cyclohexylamine)dichloroplatinum(II), carboplatin, cis-dichlorobis(isopentylamine)platinum(II), and CHIP (cis-dichloro-trans-dihydroxybis(isopropylamine)platinum(IV)). However, the sequence specificity of these analogues was similar in position and relative intensity of damage. We also provide evidence that platinum(IV) complexes can damage DNA without being reduced to platinum(II). It was found that a 10-fold higher concentration of cisplatin was required to damage DNA in Tris-HCl compared to Hepes buffers. In this paper w...Continue Reading

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Citations

Nov 13, 2002·Biochimica Et Biophysica Acta·Anne M Galea, Vincent Murray
Aug 15, 1998·Nucleic Acids Research·J WhittakerV Murray
May 16, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hieronimus W KavaVincent Murray
Jun 23, 2010·Chemical Biology & Drug Design·Anne M Galea, Vincent Murray
May 5, 1998·Chemico-biological Interactions·V MurrayW D McFadyen
Nov 5, 2005·Journal of Biomaterials Science. Polymer Edition·Jovita R Tauro, Richard A Gemeinhart
Dec 24, 2018·BMC Cancer·Ben W JohnsonMark D Temple
Jul 31, 2003·Journal of Inorganic Biochemistry·Marc S RobillardVincent Murray
Aug 10, 2017·Journal of Inorganic Biochemistry·Marcus E GraziottoElizabeth J New
Nov 30, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Anthony T S LoTrevor W Hambley

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