PMID: 8972711Dec 4, 1996Paper

Interaction of 2,4-dichlorophenoxyacetic acid (2,4-D) with cell and model membranes

Biochimica Et Biophysica Acta
M SuwalskyC P Sotomayor

Abstract

2,4-dichlorophenoxyacetic acid (2,4-D), a widely used herbicide, is a component of the "agent orange' whose toxicity has been extensively studied without definite conclusions. In order to evaluate its perturbing effect upon cell membranes, 2,4-D was made to interact with human erythrocytes and molecular models. These studies were performed by scanning electron microscopy on red cells, fluorescence spectroscopy on dimyristoylphosphatidylcholine (DMPC) large unilamellar vesicles and X-ray diffraction on multilayers of DMPC and dimyristoylphosphatidylethanolamine (DMPE). It was observed that 2,4-D induced a pronounced shape change to the erythrocytes. This effect is explained by the herbicide interaction with the outer monolayer of the red cell membrane.

References

May 12, 1987·Biochimica Et Biophysica Acta·B IsomaaG Paatero
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M P Sheetz, S J Singer
Nov 2, 1994·Biochimica Et Biophysica Acta·M SuwalskyC P Sotomayor
Feb 23, 1994·Biochimica Et Biophysica Acta·M C Antunes-MadeiraV M Madeira

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Citations

Mar 1, 2004·Environmental Toxicology and Pharmacology·Patrick DurkinGary Diamond
Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SuwalskyC P Sotomayor
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M SuwalskyL Quevedo
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M SuwalskyP Sotomayor
Mar 1, 2002·Environmental Toxicology and Pharmacology·Chrisovalantis PapaefthimiouGeorge Theophilidis
Sep 11, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Bozena Bukowska
Oct 24, 2008·Environmental Health : a Global Access Science Source·Marina Bjørling-PoulsenPhilippe Grandjean
Mar 8, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·D Arul DhasS Balachandran
Aug 17, 2011·Environmental Toxicology and Pharmacology·Anna KopkaBożena Bukowska
Dec 4, 2015·European Biophysics Journal : EBJ·Tahani H DakhakhniSafaa Y Qusti
Nov 21, 2015·Analytical and Bioanalytical Chemistry·Camila BarreraWaldo Quiroz
Apr 25, 2000·Journal of Toxicology. Clinical Toxicology·S M BradberryJ A Vale
Apr 16, 2005·Proteomics·Miguel C TeixeiraIsabel Sá-Correia
Dec 1, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bozena SzatkowskaBogumiła Huras
Jul 19, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E ArgeseP F Ghetti
Dec 15, 2008·Sensors·Vesna VasićDanijela Krstić
May 7, 2013·Physical Chemistry Chemical Physics : PCCP·Stanislav A Pshenichnyuk, Alberto Modelli
Dec 13, 2006·International Journal of Pharmaceutics·A MarczakZ Jóźwiak

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