PMID: 9438855Feb 7, 1998Paper

Interaction of a Golgi-associated kinesin-like protein with Rab6

Science
A EchardB Goud

Abstract

Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.

References

May 24, 1991·Science·A LupasJ Stock
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B J JasminJ P Changeux
Jan 1, 1982·Methods in Enzymology·R C Williams, J C Lee
Dec 1, 1994·The Journal of Cell Biology·O MartinezB Goud
Nov 1, 1994·The Journal of Cell Biology·F FeiguinA Caceres
Aug 1, 1994·Current Opinion in Cell Biology·S R Pfeffer
Dec 15, 1994·Nature·J P LianS Ferro-Novick
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S B AndrewsT S Reese
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M RenD D Sabatini
Feb 1, 1997·Current Opinion in Cell Biology·H V GoodsonT E Kreis
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·O MartinezB Goud
Jul 28, 1997·The Journal of Cell Biology·E DíazS R Pfeffer

❮ Previous
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Citations

Oct 3, 1999·Cell Motility and the Cytoskeleton·A L BomanR A Kahn
Jun 27, 2000·Journal of Cellular Physiology·S C Van IJzendoornD Hoekstra
Nov 5, 2003·Advanced Drug Delivery Reviews·John W Murray, Allan W Wolkoff
Jun 24, 2000·Biochimie·F Doussau, G J Augustine
Jul 17, 2001·Current Opinion in Cell Biology·N Segev
Jan 17, 2002·Current Opinion in Cell Biology·John A Hammer, Xufeng S Wu
Aug 28, 1998·Current Opinion in Cell Biology·G Warren, V Malhotra
Feb 19, 2000·Current Opinion in Cell Biology·X WuJ A Hammer
Feb 19, 2000·Current Opinion in Cell Biology·S L Rogers, V I Gelfand
Jul 8, 1999·Current Opinion in Neurobiology·S M Bajjalieh
Jun 17, 2000·Trends in Cell Biology·B D Manning, M Snyder
Aug 10, 2000·Trends in Cell Biology·B StorrieT Nilsson
Jan 9, 2001·Trends in Cell Biology·R Duden
Feb 21, 2002·Trends in Cell Biology·Ryan L KarcherVladimir I Gelfand
Aug 8, 1998·Trends in Cell Biology·J L StowD R Burgess
Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·J Armstrong
Jul 3, 2004·Nature Cell Biology·April C Horton, Michael D Ehlers
Jun 22, 2010·Nature Cell Biology·S Miserey-LenkeiA Echard
Jun 28, 2011·Nature Cell Biology·Daphné DambournetArnaud Echard
Jul 25, 2012·Nature Reviews. Cancer·Oliver Rath, Frank Kozielski
Jul 16, 2009·Nature Reviews. Molecular Cell Biology·Harald Stenmark
Sep 24, 2009·Nature Reviews. Molecular Cell Biology·Nobutaka HirokawaShinsuke Niwa
May 31, 2001·Immunology·J C Stinchcombe, G M Griffiths
Oct 9, 2003·Kidney International·Kristopher SchwabS Steven Potter
May 13, 2003·The Journal of Biological Chemistry·Aouatef AbazaFabienne Pirollet
Mar 12, 2008·The Journal of Biological Chemistry·Deming GouLin Liu
Dec 26, 2013·The Journal of Cell Biology·Arnaud Echard
May 15, 2002·Molecular Biology of the Cell·Xufeng WuJohn A Hammer
Jun 12, 2002·Molecular Biology of the Cell·Anne-Marie MarzescoAhmed Zahraoui
Dec 10, 1999·Molecular Biology of the Cell·E Grote, P J Novick
Feb 26, 2000·Molecular Biology of the Cell·C BucciB van Deurs
Nov 6, 2001·Molecular Biology of the Cell·H de WitP van der Sluijs

❮ Previous
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