Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization

Science
D J BurksP Saling

Abstract

A 95-kilodalton mouse sperm protein with characteristics of a protein tyrosine kinase has been identified as a receptor for ZP3, a glycoprotein in the egg's extracellular matrix. The structure of the human homolog was determined by screening an expression library from human testis; a testis-specific complementary DNA was isolated that encodes a protein similar to receptor tyrosine kinases and appears to be expressed only in testicular germ cells. Antibodies against a synthetic peptide from the intracellular domain recognized a 95-kilodalton human sperm protein that contains phosphotyrosine; human ZP3 stimulates the kinase activity of this sperm protein. Synthetic peptides corresponding to regions of the predicted extracellular domain inhibited sperm binding to human zona pellucida. Availability of the primary sequence of a receptor for ZP3 provides a rational starting point for sperm-targeted contraceptive development.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L LeytonP M Saling
Feb 1, 1992·Current Opinion in Genetics & Development·T Pawson
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M E Chamberlin, J Dean
Jan 1, 1987·Methods in Enzymology·M SnyderR W Davis
May 9, 1988·Journal of Immunological Methods·J R GlenneyM P Kamps
Jun 1, 1989·The Journal of Cell Biology·L Leyton, P Saling
Feb 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·D R FrankenG D Hodgen
Jan 1, 1988·Annual Review of Biochemistry·Y Yarden, A Ullrich
Jan 1, 1986·Advances in Protein Chemistry·M S Briggs, L M Gierasch
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Mar 12, 1993·Cell·Z SongyangR J Lechleider
Feb 1, 1994·Current Opinion in Genetics & Development·A Kazlauskas
Mar 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Panayotou, M D Waterfield
May 1, 1993·Molecular Reproduction and Development·S OehningerG D Hodgen

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Citations

Feb 1, 1997·Molecular Reproduction and Development·J Capková, J Pĕknicová
Jan 28, 1998·Molecular Reproduction and Development·K AshizawaY Tsuzuki
Jan 28, 1998·Molecular Reproduction and Development·N TanphaichitrD White
Apr 21, 1998·Molecular Reproduction and Development·C MorteP Martínez
Oct 15, 1998·Molecular Reproduction and Development·P KalabJ Moos
May 7, 1999·Molecular Reproduction and Development·K U DeviS Shivaji
Jun 22, 2000·Molecular Reproduction and Development·E RivkinA L Kierszenbaum
Dec 31, 2002·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Isurani Ilayperuma
Aug 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M Kozak
Feb 3, 2012·Cell and Tissue Research·Satish K GuptaNeha Gupta
Jun 13, 2003·Fertility and Sterility·Andrea LasserreMónica H Vazquez-Levin
May 31, 1996·Cell·W J Snell, J M White
Dec 4, 2001·Journal of Reproductive Immunology·Haim Breitbart
Dec 4, 2001·Journal of Reproductive Immunology·Elisabetta BaldiGianni Forti
Feb 1, 1997·Journal of Reproductive Immunology·P PöllänenB P Setchell
Oct 24, 2000·Biology of the Cell·C PatratP Jouannet
May 4, 2002·Molecular and Cellular Endocrinology·Haim Breitbart
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·Z Naor, H Breitbart
Sep 7, 2001·Cytokine & Growth Factor Reviews·A SingsonP Kadandale
Jun 13, 2008·Journal de la Société de biologie·Catherine SerresPierre Jouannet
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·V KurvariW J Snell
Jul 31, 2013·Omics : a Journal of Integrative Biology·Margarida FardilhaEdgar F da Cruz e Silva
Jan 15, 2013·Human Reproduction·Gary F Clark
Mar 1, 1996·American Journal of Reproductive Immunology : AJRI·R J AitkenM van Duin
Jan 20, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Patricia GrasaJosé Alvaro Cebrián-Pérez
Oct 16, 2012·Fertility and Sterility·Woo-Sung KwonMyung-Geol Pang
Oct 24, 2009·Journal of Reproductive Immunology·Satish K GuptaKausiki Chakrabarti
May 23, 1998·The Journal of Urology·M E FallatD T MacLaughlin

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