Interaction of acyclovir and its squalenoyl-acyclovir prodrug with DMPC in monolayers at the air/water interface

International Journal of Pharmaceutics
Maria Grazia SarpietroFrancesco Castelli

Abstract

Acyclovir has been conjugated to the acyclic isoprenoid chain of squalene to form the squalenoyl-acyclovir prodrug. Its interaction with biomembrane models constituted by dimyristoylphosphatidylcholine (DMPC) monolayers has been studied by employing the Langmuir-Blodgett technique. The aim of the work was to gain information on the interaction of these compounds with phospholipid membranes. DMPC/acyclovir or squalenoyl-acyclovir prodrug mixed monolayers have been prepared at increasing molar fractions of the compound and the isotherm mean molecular area/surface pressure has been registered at 10 and 37 degrees C. Results reveal that the squalenoyl moiety enhances the affinity of acyclovir for the biomembrane model.

References

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Aug 19, 2009·International Journal of Pharmaceutics·Maria Grazia SarpietroFrancesco Castelli

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Citations

Apr 16, 2013·International Journal of Pharmaceutics·Lina DuJunxing Dong
Mar 7, 2014·Journal of Colloid and Interface Science·Maria G SarpietroFrancesco Castelli
Feb 2, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Dorota MatyszewskaJacek Lipkowski
Oct 20, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Barbara StellaLuigi Cattel
Jun 26, 2012·International Journal of Pharmaceutics·Maria Grazia SarpietroFrancesco Castelli
Feb 23, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Dorota MatyszewskaRenata Bilewicz
Jul 31, 2013·Journal of Natural Products·Maria Grazia SarpietroFrancesco Castelli

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