Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

Oncogene
A BursenR Marschalek

Abstract

The human AF4 (ALL-1 fused gene on chromosome 4) gene (4q11) is recurrently involved in reciprocal translocations to the MLL (mixed lineage leukemia) gene (11q23), correlated with high-risk acute lymphoblastic leukemia (ALL) in infants and early childhood. The t(4;11) translocation is one of the most frequent MLL translocations known today. In general, MLL translocations are the result of an illegitimate recombination process leading to reciprocal fusions of unrelated translocation partner (TP) genes with the MLL gene. Owing to the constant presence of the derivative (11) product, it was hypothesised that only MLL.TP fusion genes are responsible for the leukemogenic process. This concept has been successfully tested for some known MLL fusions, while other MLL fusions failed. Here, we demonstrate growth-transforming potential of AF4 wild-type and the AF4.MLL fusion protein. The underlying oncogenic mechanism involves the two E3 ubiquitin ligases SIAH1 and SIAH2, the N-terminal portion of AF4 and the protection of the AF4.MLL fusion protein against proteosomal degradation.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Gossen, H Bujard
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P H DomerS J Korsmeyer
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·S A SchichmanC M Croce
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·R PrasadE Canaani
Jan 1, 1996·Genetic Analysis : Biomolecular Engineering·J L FrestedtJ H Kersey
Feb 1, 1996·Human Molecular Genetics·L ChakrabartiK E Davies
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·T YanoE Canaani
Jun 24, 1998·Genes & Development·J ZhangM A Lazar
Jun 23, 1999·Current Opinion in Genetics & Development·M van Lohuizen
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L LorickA M Weissman
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·T TakiY Hayashi
Dec 22, 1999·Oncogene·H Bruzzoni-GiovanelliF Calvo
Apr 5, 2000·The Journal of Biological Chemistry·J TanikawaS Ishii
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·C LavauM J Thirman
Aug 3, 2001·The EMBO Journal·J BoehmT Wirth
Dec 14, 2001·Nature Structural Biology·Galina PolekhinaDavid D L Bowtell
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SusiniA Telerman
Aug 31, 2002·Genes, Chromosomes & Cancer·Anne R M von BerghEd Schuuring
Nov 7, 2002·Cell·Bryan M Turner
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Colin M HouseDavid D L Bowtell
Sep 4, 2003·Genes & Development·Paul M Ayton, Michael L Cleary

❮ Previous
Next ❯

Citations

May 24, 2013·Cell Biochemistry and Biophysics·Jianfei QiZe'ev A Ronai
Oct 6, 2012·Leukemia·O H KrämerS K Knauer
May 1, 2013·Leukemia·C MeyerR Marschalek
Aug 17, 2012·Nature Reviews. Molecular Cell Biology·Zhuojuan LuoAli Shilatifard
Mar 3, 2006·Leukemia·C MeyerR Marschalek
Nov 19, 2010·The Journal of Biological Chemistry·Carolin BierRoland H Stauber
Apr 18, 2009·Molecular Cancer Research : MCR·Koh NakayamaZe'ev Ronai
Oct 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Peter L OliverKay E Davies
Nov 16, 2010·Leukemia Research·Rolf Marschalek
Aug 25, 2005·Hematological Oncology·Robert K Slany
Jun 30, 2009·European Journal of Haematology·Luca TrentinRolf Marschalek
Aug 8, 2006·Biotechnology Journal·Claus MeyerRolf Marschalek
Dec 2, 2010·British Journal of Haematology·Rolf Marschalek
Jun 21, 2012·British Journal of Haematology·Bastian Scholz, Rolf Marschalek
Aug 26, 2014·Chembiochem : a European Journal of Chemical Biology·Johannes van den BoomMarkus Kaiser
Mar 6, 2015·Archiv der Pharmazie·Rolf Marschalek
Jan 1, 2012·Cancers·Erica Ballabio, Thomas A Milne
Dec 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Oliver H KrämerThorsten Heinzel
Sep 8, 2019·Cellular Oncology (Dordrecht)·Tiziana FiorettiGabriella Esposito
Jul 14, 2017·Leukemia·C MeyerR Marschalek
Apr 16, 2005·Clinical Science·Peter L Oliver, Kay E Davies
Apr 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cody A CunninghamMark A Daniels
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claus MeyerRolf Marschalek
Apr 30, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Subham BasuDebabrata Biswas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.