Interaction of amiloride with rat parotid muscarinic and alpha-adrenergic receptors

General Pharmacology
J P Dehaye, V Verhasselt

Abstract

1. In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine. 2. Amiloride competitively inhibited the binding of [3H]N-methylscopolamine and [3H] is thus a competitive antagonist of muscarinic and norepinephrine alpha-adrenergic receptors. 3. Amiloride did not affect the response to substance P with respect to secretion or ion movements. 4. Thus the Na+/H+ antiporter is not involved in the short-term regulation of amylase secretion and calcium and potassium movements in rat parotid gland function.

References

Jan 1, 1985·Archives of Oral Biology·J P DehayeP Van Bogaert
Jun 1, 1988·The Journal of Membrane Biology·M Manganel, R J Turner
Apr 14, 1986·Biochemical and Biophysical Research Communications·C W TaylorR P Rubin
Jun 15, 1987·Biochemical and Biophysical Research Communications·J E MelvinR J Turner
Jan 1, 1948·Helvetica Chimica Acta·G NOELTING, P BERNFELD

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Citations

Apr 29, 2014·Trends in Biochemical Sciences·Vsevolod KatritchRaymond C Stevens
Sep 26, 2019·Pharmacological Reviews·Barbara ZarzyckaVsevolod Katritch
Apr 21, 2021·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·A M Beal

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