Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes

Journal of Ethnopharmacology
Chang-Hua ZhangGuo-Liang Xu

Abstract

Baicalin and berberine are important coexisting constituents of the combination of Radix Scutellariae and Rhizoma Coptidis, known as scutellaria-coptis herb couple (SC), which has heat clearing and detoxifying effects. The aims of the present study were to investigate the effects of the combination of baicalin+berberine on glucose uptake in 3T3-L1 adipocytes or HepG2 cells. Insulin-resistant adipocytes and hepatocytes models were established. Glucose consumption was assayed to evaluate the effects of berberine, baicalin, and berberine+baicalin on glucose uptake, and the interaction of baicalin with berberine for glucose uptake was evaluated in 3T3-L1 adipocytes or HepG2 cells. Moreover, the effects of baicalin on the dose-effect relationship of berberine for glucose uptake was also evaluated in 3T3-L1 adipocytes. The results of the present study demonstrated that berberine increased glucose consumption in 3T3-L1 adipocytes and HepG2 hepatocytes in a dose-dependent manner. In contrast, statistical analyses indicated that baicalin (in doses up to 100μmol/L) produced no obvious effect. The effect of berberine+baicalin on glucose uptake was better than that of berberine or baicalin alone, which indicated that berberine and baicalin...Continue Reading

References

Oct 21, 1999·European Journal of Pharmacology·I DubucJ Costentin
Oct 24, 2002·Anaesthesia·P C A Kam, S Liew
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Ping XieHui-Ping Song
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Ronald J TallaridaRobert B Raffa
Dec 12, 2003·Phytotherapy Research : PTR·Wei JiaLida Tang
Sep 11, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Li Yi, Xu Xu
Feb 3, 2005·Nature Reviews. Drug Discovery·Curtis T KeithBrent R Stockwell
Aug 18, 2005·Clinical Science·Christine M KusminskiSudhesh Kumar
Jun 7, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Weidong XieLijun Du
Feb 13, 2007·Metabolism: Clinical and Experimental·Libin ZhouJialun Chen
Nov 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jun YinJianping Ye
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lan WangZhu Chen
Jun 10, 2008·Endocrine, Metabolic & Immune Disorders Drug Targets·Jun YinJianping Ye
Dec 25, 2008·Phytotherapy Research : PTR·Mak-Soon LeeYangha Kim
May 14, 2011·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Xiao-Lin TongHang-Yu Ji
May 10, 2012·Journal of Ethnopharmacology·De-an GuoLiang Liu
Jun 13, 2012·Chemical & Pharmaceutical Bulletin·Jing-Rong WangZhi-Hong Jiang
Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chang-Hua ZhangLiang Tao

❮ Previous
Next ❯

Citations

Feb 13, 2016·Pharmaceutical Biology·Xuansheng HuZhenya Zhang
Jun 21, 2015·European Journal of Pharmacology·Anil KumarDinesh K Dhull
Sep 6, 2018·Journal of Applied Toxicology : JAT·Weijia HanZhongping Duan
May 2, 2018·Current Medicinal Chemistry·Maria-Ioanna ChristodoulouMaria Halabalaki
Feb 6, 2020·Pharmacological Reports : PR·Penghua FangZhenwen Zhang
Oct 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi Shin EngJung San Chang
May 25, 2021·Frontiers in Pharmacology·Jing-Ze LuBing-Liang Ma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Hongying ChenJinfeng Wu
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Xiao-qiang WangXin Zou
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Zhao-Tang MaGuoyue Zhong
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Rui ZhangYujie Zhang
© 2021 Meta ULC. All rights reserved