Interaction of biologically active amines with mitochondria and their role in the mitochondrial-mediated pathway of apoptosis

Current Medicinal Chemistry
Antonio ToninelloB Mondovi

Abstract

The natural polyamines spermine, spermidine and putrescine, polycationic molecules at physiological pH, interact with mitochondrial membranes at two specific binding sites exhibiting low affinity and high binding capacity. This binding represents the first step in the electrophoretic mechanism of polyamine transport into mitochondria. Spermine accumulated into the mitochondrial matrix is able to flow out by an electroneutral mechanism. This process promotes bi-directional transport of polyamines in and out of mitochondria, driven by electrical potential and pH gradient, respectively. Polyamines and biogenic amines are oxidized by cytosolic and mitochondrial amine oxidases with the production of hydrogen peroxide and aldehydes, both of which are involved in the induction and/or amplification of the mitochondrial permeability transition (MPT). This phenomenon, which provokes a bioenergetic collapse and redox catastrophe, is strongly inhibited by polyamines in isolated mitochondria. Monoamines also exhibit an inhibitory effect at higher concentrations, but at low concentrations behave as inducer agents. MPT is characterized by the opening of a channel, the transition pore, which permits non-specific bi-directional traffic of solut...Continue Reading

Citations

Sep 14, 2006·Acta Neuropathologica·Jörg BäurleSabine Frischmuth
Dec 21, 2007·Amino Acids·M P M MarquesA Toninello
Dec 17, 2009·Amino Acids·E AgostinelliA Toninello
Aug 3, 2011·Amino Acids·Valentina BattagliaAntonio Toninello
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·M SchillerH M Lorenz
Sep 21, 2011·Molecular Neurobiology·Yi-Zhi Wang, Tian-Le Xu
Apr 28, 2005·Free Radical Biology & Medicine·Mauro SalviAntonio Toninello
Mar 9, 2013·Journal of Medicinal Chemistry·O PrezzaventoS Ronsisvalle
Aug 17, 2011·Chemical Research in Toxicology·Lisa A PetersonMathilde M Sullivan
Mar 27, 2009·American Journal of Physiology. Cell Physiology·Mary Ann ArndtJoseph Satriano
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bo DuanTian-Le Xu
Sep 18, 2013·Amino Acids·Silvia GrancaraAntonio Toninello
Jan 31, 2006·Journal of Pineal Research·Andrew W SiuRussel J Reiter
Nov 28, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Zhi-Gang Xiong, Tian-Le Xu
Oct 30, 2013·Chemical Biology & Drug Design·Eduardo Coelho-CerqueiraCristian Follmer
Oct 18, 2005·Biochimica Et Biophysica Acta·Antonio ToninelloBruno Mondovì
Jan 17, 2015·Free Radical Biology & Medicine·Emanuela BonaiutoMaria Luisa Di Paolo
Sep 10, 2014·Regulatory Toxicology and Pharmacology : RTP·Mozhgan Sedigh-ArdekaniHossein Mirkhani
Dec 8, 2009·Biochemical and Biophysical Research Communications·Brooke E ChristianLinda L Spremulli
Sep 30, 2016·Amino Acids·Enzo Agostinelli
Oct 4, 2006·Free Radical Biology & Medicine·Irina G SavaAntonio Toninello
Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea ScozzafavaFabrizio Carta
Nov 3, 2006·Electrophoresis·Tai-Chia ChiuHuan-Tsung Chang
Apr 3, 2014·Physiological Reviews·Ildiko Szabo, Mario Zoratti
Feb 6, 2020·Plant, Cell & Environment·Jing CuiGuillaume Tcherkez
Jun 20, 2007·The Journal of Biological Chemistry·Mauro SalviAntonio Toninello
Mar 3, 2006·The Biochemical Journal·Mauro SalviAntonio Toninello
Oct 5, 2016·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Agnieszka MielcarekAnna Dołęga
Jun 20, 2018·Cell Death and Differentiation·Julie-Myrtille BourgognonJoern R Steinert

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