PMID: 2495582Mar 1, 1989Paper

Interaction of cadmium with brush border membrane vesicles from the rat small intestine

Toxicology
C Bevan, E C Foulkes

Abstract

Cd2+ uptake by brush border membrane vesicles isolated from rat small intestine was investigated by a rapid filtration technique. Cd2+ uptake showed time- and temperature-dependence. Changes in medium osmolarity had no effect on Cd2+ uptake, indicating that the process involves primarily binding of Cd2+ to membrane component(s). Membrane-impermeable chelating agents removed only about 60-65% of the bound cadmium from intact vesicles preincubated with Cd; almost all Cd was removed by chelators when membrane permeability was increased by 1-butanol. Thus Cd uptake by membrane vesicles results in binding to both sides of the membrane. Pretreatment of vesicles with cadmium resulted in a time-dependent inhibition of D-glucose uptake in the presence of a sodium (but no potassium) gradient. This inhibition is correlated with Cd binding to external sites on the D-glucose transporter, and not the driving force for D-glucose transport.

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Citations

Jul 8, 1999·Journal of Cellular Physiology·C JumarieF Denizeau
May 1, 1993·Biological Trace Element Research·M C Rodriguez YoldiM J Rodriguez Yoldi
Jan 1, 1996·Biological Trace Element Research·M C Rodriguez YoldiM J Rodriguez Yoldi
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May 1, 1996·Biological Trace Element Research·J E MesoneroM J Rodriguez Yoldi
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May 16, 1997·Toxicology Letters·Y Lind, A Wicklund Glynn
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Mar 13, 2012·Biological Reviews of the Cambridge Philosophical Society·Hill Malcolm, Hill April
Aug 1, 1990·Journal of Neurochemistry·B Shi, A Haug
Aug 17, 2005·Industrial Health·Kazuhiro SatoOsamu Yokoyama
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Sep 21, 2005·Journal of Biochemical and Molecular Toxicology·I Aduayom, C Jumarie
Oct 24, 2007·Chemico-biological Interactions·Lysandro Pinto BorgesGilson Zeni
Aug 1, 1997·Human & Experimental Toxicology·B ElsenhansS G Schäfer
Nov 1, 1992·Zentralblatt für Veterinärmedizin. Reihe A·M C Rodríguez YoldiM J Rodríguez Yoldi
Jul 1, 1994·Research in Veterinary Science·M C Rodríguez-YoldiM J Rodríguez-Yoldi

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