Interaction of choline with nicotinic and muscarinic cholinergic receptors in the rat brain in vitro

Clinical and Experimental Pharmacology & Physiology
L G Costa, S D Murphy

Abstract

The ability of choline to interact with nicotinic receptors was investigated by measuring its ability to inhibit the specific binding of [3H]-nicotine in rat brain. Choline, with an IC50 of 241 mumol/l, was three times more potent than its analogue deanol and almost 1000-fold less potent than acetylcholine. Choline also inhibited the binding of the antagonist [3H]-quinuclidinyl benzilate (IC50 = 2.5 mmol/l) and of the agonist [3H]-oxotremorine-M (IC50 = 165 mumol/l) to muscarinic cholinergic receptors. These results indicate that choline is able to interact directly, in vitro with brain cholinergic receptors of both the nicotinic and muscarinic type.

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Citations

Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·L G CostaS D Murphy
Aug 10, 2007·Visual Neuroscience·Christianne E StrangKent T Keyser
Mar 28, 1998·The European Journal of Neuroscience·M AlkondonE X Albuquerque
Dec 14, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F BorrelliA A Izzo
Jun 18, 2011·Brain Research·Xianghong ArakakiMichael G Harrington
Sep 1, 1987·Human Toxicology·S Wonnacott
May 6, 2005·American Journal of Physiology. Cell Physiology·Christianne E StrangKent T Keyser
Oct 10, 2014·Journal of Neurophysiology·Christianne E StrangKent T Keyser
Mar 14, 2019·Annals of the Rheumatic Diseases·Erika Van NieuwenhoveAdrian Liston
Dec 13, 1988·Brain Research·N J Cairns, S Wonnacott
Sep 9, 2021·Journal of Neurophysiology·Erin L GrafeBrian R Christie

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