PMID: 7541279Apr 1, 1995Paper

Interaction of clozapine with the histamine H3 receptor in rat brain

British Journal of Pharmacology
A A RodriguesG D Prell

Abstract

We examined possible interactions between neuroleptics and the histamine H3 receptor and found an interaction of clozapine with this receptor. In competition binding experiments, using the H3 antagonist, [125I]-iodophenpropit, we observed a Ki of 236 +/- 87 nM. Functionally, clozapine was studied on the H3-mediated inhibition of [3H]-5-hydroxytryptamine ([3H]-5-HT) release from rat brain cortex slices. Clozapine acts as an antagonist with an apparent KB value of 79.5 nM.

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Citations

Mar 1, 1996·Psychopharmacology·B J Kinon, J A Lieberman
Jan 1, 1996·Neuropharmacology·G D BartoszykH Ziegler
Jul 4, 1998·Trends in Pharmacological Sciences·R LeursH Timmerman
Jan 19, 2000·Trends in Pharmacological Sciences·R LeursH Timmerman
Dec 1, 1996·Epilepsy Research·J R StevensP Szot
Aug 1, 1996·British Journal of Pharmacology·A Alves-RodriguesH Timmerman
May 15, 2012·Pharmacological Reports : PR·Danish MahmoodMohd Akhtar
Apr 29, 1998·The Tohoku Journal of Experimental Medicine·C ItoT Watanabe
Jul 27, 2006·Fundamental & Clinical Pharmacology·Mohd AkhtarDivya Vohora
Sep 18, 2015·Journal of Experimental Neuroscience·D MahmoodM Akhtar
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Apr 19, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Danish MahmoodDipanjan Goswami

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