Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A

Circulation
C J DoggenF R Rosendaal

Abstract

A genetic variation located in the 3'-untranslated region of the prothrombin gene (prothrombin 20210 G-->A) was recently described as a risk factor for venous thrombosis. We examined how the presence of this mutation affected the risk of myocardial infarction in a population-based case-control study. Furthermore, we studied the risk of myocardial infarction associated with the simultaneous presence of a coagulation defect (ie, the 20210 AG genotype of prothrombin or the factor V Leiden mutation) and Major cardiovascular risk factors. Among 560 men with a first myocardial infarction before the age of 70 years, 1.8% were heterozygous carriers of the 20210 variant of the prothrombin gene. The control group consisted of 646 men who were frequency matched by age. In the latter group, the frequency of the 20210 AG genotype was 1.2%. The risk of myocardial infarction in the presence of the AG genotype was increased by 50% (odds ratio, 1.5; 95% confidence interval [95% CI], 0.6 to 3.8). The risk of myocardial infarction for carriership of factor V Leiden mutation was increased by 40% (odds ratio, 1.4; 95% CI, 0.8 to 2.2). When a coagulation defect was present (ie, the 20210 AG prothrombin genotype or the factor V Leiden mutation), the ...Continue Reading

Citations

Mar 6, 2007·Journal of Thrombosis and Thrombolysis·Fuat GundogduHuseyin Senocak
Sep 27, 2012·Journal of Thrombosis and Thrombolysis·R DajaniF Quadan
Oct 18, 2013·Neuroscience Bulletin·Thierry Paluku They-TheySellama Nadifi
May 18, 2005·Experimental and Molecular Pathology·T AngelineGregory J Tsongalis
Nov 25, 2000·The American Journal of Cardiology·L F WateletD Ryan
Dec 12, 2001·Clinical Biochemistry·A HumenyC M Becker
May 3, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ercüment OvaliPolat Koşucu
May 24, 2003·Best Practice & Research. Clinical Haematology·Isobel D Walker
Oct 29, 2000·British Journal of Haematology·C J DoggenF R Rosendaal
Sep 13, 2001·British Journal of Haematology·UNKNOWN Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology
Dec 12, 2001·British Journal of Haematology·R F Franco, P H Reitsma
Oct 3, 2003·The New England Journal of Medicine·Giacomo Colussi
Mar 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Talya WolakGilles Lugassy
Nov 11, 1999·Current Opinion in Lipidology·T G DeLoughery
Sep 1, 1999·Current Opinion in Hematology·M V Huisman, F Rosendaal
Sep 24, 2005·Transplantation·Santiago G MiriukaDavid E C Cole
Dec 1, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jody Lynn Kujovich
Feb 24, 2001·Molecular Pathology : MP·T C SykesD Mosquera
Aug 31, 2004·Tobacco Control·M S MähönenUNKNOWN WHO MONICA Project
Jul 17, 2008·Journal of Translational Medicine·Pierpaolo Di MiccoGiuseppe Castaldo
Oct 1, 2011·Journal of Cardiothoracic Surgery·Ozan EmirogluNejat Akar
May 29, 2009·Clinical Medicine & Research·Kirk J HoganMichael J Domanico
Sep 19, 2003·Wiener klinische Wochenschrift·Herbert H Watzke
Feb 9, 2002·American Journal of Hematology·W Y AuC C K Lam
Jul 21, 2010·Genetic Testing and Molecular Biomarkers·Moataz Dowaidar, Ahmad Settin
Oct 5, 2006·Current Opinion in Anaesthesiology·Sunitha GovindaswamyAlain Vuylsteke
Mar 27, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R ZahnJ Senges
May 8, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R Ben-AmiS A Berliner
Nov 20, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E Durante-MangoniK Michaelides
May 5, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Meral KaykçoğluCuneyt Turkoglu
May 3, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Adriano de Paula SabinoAna Paula Fernandes
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M G van PampusP H Reitsma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.