Interaction of coffee compounds with serum albumins. Part II: Diterpenes

Food Chemistry
Elena GuerciaFederico Berti

Abstract

Cafestol and 16-O-methylcafestol are diterpenes present in coffee, but whilst cafestol is found in both Coffea canephora and Coffea arabica, 16-O-methylcafestol (16-OMC) was reported to be specific of only C. canephora. The interactions of such compounds, with serum albumins, have been studied. Three albumins have been considered, namely human serum albumin (HSA), fatty acid free HSA (ffHSA) and bovine serum albumin (BSA). The proteins interact with the diterpenes at the interface between Sudlow site I and the fatty acid binding site 6 in a very peculiar way, leading to a significant change in the secondary structure. The diterpenes do not displace reference binding drugs of site 2, but rather they enhance the affinity of the site for the drugs. They, therefore, may alter the pharmacokinetic profile of albumin - bound drugs.

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Citations

Jun 17, 2016·Phytotherapy Research : PTR·Md Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
Jul 18, 2016·Journal of Photochemistry and Photobiology. B, Biology·Saad TayyabZazali Alias
Mar 24, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Christina PapaemmanouilAndreas G Tzakos
Jun 23, 2019·Journal of Biomolecular Structure & Dynamics·Amer M AlanaziMohammad Hassan Baig
May 14, 2020·Journal of Biomolecular Structure & Dynamics·Saad TayyabSaharuddin B Mohamad
Mar 12, 2020·International Journal of Molecular Sciences·Federico BertiCristina Forzato
Sep 26, 2019·Journal of Biomolecular Structure & Dynamics·Salanee KandandapaniSaad Tayyab
Sep 15, 2019·Food Chemistry·Paulo Henrique C PaivaAna Clarissa Dos S Pires

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