Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala

The Journal of Pharmacology and Experimental Therapeutics
Maenghee Kang-ParkScott D Moore

Abstract

The corticotropin-releasing factor (CRF) and kappa-opioid receptor (KOR) systems are both implicated in stress-related behaviors and drug dependence. Although previous studies suggest that antagonism of each system blocks aspects of experimental models of drug dependence, the possible interaction between these systems at the neuronal level has not been completely examined. We used an in vitro brain slice preparation to investigate the interaction of these two peptide systems on inhibitory neurotransmission in the central nucleus of the amygdala (CeA). Application of exogenous CRF increased the mean frequency of GABAergic miniature inhibitory postsynaptic currents (mIPSC) by 20.2%, suggesting an increase in presynaptic GABA release. Although the pharmacological blockade of KORs by norBNI alone did not significantly affect mIPSC frequency, it significantly enhanced the effect of CRF (by 43.9%, P = 0.02). Similarly, the CRF effects in slices from KOR knockout (KO) mice (84.0% increase) were significantly greater than in wild-type (WT) mice (24.6%, P = 0.01), although there was no significant difference in baseline mIPSC frequency between slices from KOR KO and WT mice. The increase in CRF action in the presence of norBNI was aboli...Continue Reading

References

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Apr 17, 2013·The Journal of Pharmacology and Experimental Therapeutics·Maenghee Kang-ParkScott D Moore
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Citations

Apr 21, 2017·Alcoholism, Clinical and Experimental Research·Rachel I Anderson, Howard C Becker
Jul 31, 2020·Journal of Neuroscience Research·Anna M W TaylorChristopher J Evans
Jun 24, 2018·Nature Reviews. Neuroscience·Emmanuel Darcq, Brigitte Lina Kieffer
Dec 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachel I AndersonHoward C Becker
Dec 22, 2020·Neurobiology of Stress·Sarah C SimmonsFereshteh S Nugent
Mar 20, 2020·Neuropharmacology·Volker NeugebauerFrank Porreca
Apr 23, 2017·Neuropharmacology·Howard C Becker

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