PMID: 8611599Jan 12, 1996Paper

Interaction of dipyridamole with lipids in mixed Langmuir monolayers

Biochimica Et Biophysica Acta
G P BorissevitchO N Oliveira

Abstract

Dipyridamole (DIP), a well known coronary vasodilator and coactivator of anti-tumor activity of a number of drugs, forms stable Langmuir monolayers with the zwitterionic lipid dipalmitoylphosphatidylcholine (DPPC) and the negatively charged dipalmitoylphosphatidylglycerol (DPPG) at an air/aqueous solution interface. The drug binds to the lipid molecules and change their packing density in the monolayer in the process of compression, the effect depending on the drug location in the monolayer, protonation of the drug and also on the charge state of the lipid. The incorporation of dipyridamole (DIP) into neutral DPPC monolayers causes them to be more expanded at low DIP concentrations but more condensed at high concentrations, resembling the effect of cholesterol. Maximum expansion occurs for a DIP concentration of 2 mol%. For slightly charged DPPG monolayers spread on ultra pure water, the monolayers become increasingly more expanded with increasing DIP concentrations. For the negatively charged DPPG monolayers spread on buffer solutions, the incorporation of DIP has similar effects to that observed for DPPC monolayers. This is probably due to the interaction between the charged DPPG molecules and the protonated DIP molecules. Al...Continue Reading

References

Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·N Ramu, A Ramu
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H ScheuermannJ W Uhr
Aug 23, 1995·Biochimica Et Biophysica Acta·I E BorissevitchM Tabak

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Citations

Nov 10, 2000·Journal of Photochemistry and Photobiology. B, Biology·P P KnoxG P Borissevitc
Jul 10, 2012·Colloids and Surfaces. B, Biointerfaces·Luiz C SalayShirley Schreier
Mar 7, 2009·Chemical Reviews·Stefan Balaz
Jan 18, 2008·Biophysical Journal·Susan L Duncan, Ronald G Larson
Aug 2, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Luiz C SalayValtencir Zucolotto
Aug 12, 2009·Biochimica Et Biophysica Acta·Daniella T TalhariAna Paula U Araújo
Oct 7, 1997·Biochimica Et Biophysica Acta·P M NassarM Tabak
May 17, 2005·Colloids and Surfaces. B, Biointerfaces·Olga Berdysheva-DésertMichèle Saint-Pierre-Chazalet
Jul 1, 2008·Biochimica Et Biophysica Acta·Thais F SchmidtOsvaldo N Oliveira
Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M RodriguesJ R Perussi
Apr 6, 2018·Journal of the Royal Society, Interface·Ian Williams, Todd M Squires
Sep 10, 2003·Journal of Colloid and Interface Science·J MiñonesE Iribarnegaray

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