Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms

The Journal of Pediatrics
Katja BeckerManfred Laucht

Abstract

To demonstrate that children homozygous for the 10-repeat allele of the common dopamine transporter (DAT1) polymorphism who were exposed to maternal prenatal smoke exhibited significantly higher hyperactivity-impulsivity than children without these environmental or genetic risks. We performed a prospective longitudinal study from birth into early adulthood monitoring the long-term outcome of early risk factors. Maternal prenatal smoking was determined during a standardized interview with the mother when the child was 3 months old. At age 15 years, 305 adolescents participated in genotyping for the DAT1 40 base pair variable number of tandem repeats polymorphism and assessment of inattention, hyperactivity-impulsivity, and oppositional defiant/conduct disorder symptoms with the Kiddie-Sads-Present and Lifetime Version. There was no bivariate association between DAT1 genotype, prenatal smoke exposure and symptoms of attention deficit hyperactivity disorder. However, a significant interaction between DAT1 genotype and prenatal smoke exposure emerged (P = .012), indicating that males with prenatal smoke exposure who were homozygous for the DAT1 10r allele had higher hyperactivity-impulsivity than males from all other groups. In fem...Continue Reading

References

Nov 18, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M LauchtM H Schmidt
Apr 22, 1999·The British Journal of Psychiatry : the Journal of Mental Science·A ThaparR Harrington
Jul 16, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·M M WeissmanD B Kandel
Aug 22, 2000·European Journal of Nuclear Medicine·J LavalayeE A van Royen
Oct 12, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·M LauchtM H Schmidt
Jan 10, 2001·JAMA : the Journal of the American Medical Association·C L LeibsonP C O'Brien
Jun 8, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·M ErnstM L Robinson
Aug 10, 2001·American Journal of Epidemiology·K WisborgN J Secher
Nov 28, 2002·Psychiatric Genetics·Brion S MaherMichael M Vanyukov
Aug 13, 2003·Archives of General Psychiatry·E Jane CostelloAdrian Angold
Sep 11, 2004·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Manfred Laucht, Martin H Schmidt
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Jul 25, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johanna KrauseManfred Ackenheil
Nov 2, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Manfred LauchtMartin H Schmidt

❮ Previous
Next ❯

Citations

May 1, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Michael Huss
Jun 10, 2009·Human Genetics·Ian R GizerIrwin D Waldman
Dec 22, 2009·European Child & Adolescent Psychiatry·Anne-Kathrin WermterKatja Becker
Feb 12, 2010·European Child & Adolescent Psychiatry·Nanda N J RommelseJan K Buitelaar
May 15, 2012·Journal of Abnormal Child Psychology·Michael T WilloughbyUNKNOWN Family Life Project Investigators
Dec 1, 2009·Attention Deficit and Hyperactivity Disorders·Kouichi YoshimasuUNKNOWN Wakayama ADHD Study Group
Jan 15, 2009·Developmental Neuropsychology·Valerie S Knopik
Sep 4, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Erik G WillcuttRichard K Olson
Jun 16, 2009·The Journal of Nervous and Mental Disease·Scott H KollinsAllison E Ashley-Koch
Jun 18, 2009·Current Opinion in Neurology·Marie D Cornelius, Nancy L Day
May 12, 2010·Addiction Biology·Aryeh I Herman, Mehmet Sofuoglu
Sep 10, 2011·Archives of Disease in Childhood·Anita ThaparEvangelia Stergiakouli
Dec 24, 2010·Italian Journal of Pediatrics·Paolo CuratoloRomina Moavero
Aug 10, 2013·American Journal of Public Health·Brian M D'OnofrioPaul Lichtenstein
Jan 1, 2010·Pharmacogenomics and Personalized Medicine·Darko TuricEdmund Sonuga-Barke
Sep 26, 2013·Neurotoxicology and Teratology·T Caitlin O'BrienLauren S Wakschlag
May 14, 2014·Neurotoxicology and Teratology·Michelle M Martel, Bethan A Roberts
Aug 12, 2014·Current Problems in Pediatric and Adolescent Health Care·Sherry ZhouMichael Weitzman
Dec 18, 2013·Development and Psychopathology·Theodore P Beauchaine, Tiffany McNulty
Aug 21, 2013·Current Problems in Pediatric and Adolescent Health Care·Michael WeitzmanDavid E Jacobs
Mar 20, 2013·Molecular Aspects of Medicine·Akula Bala PramodL Keith Henry
Apr 13, 2011·Clinical Psychology Review·Ursula Pauli-Pott, Katja Becker
Sep 14, 2010·Economics and Human Biology·Petter Lundborg, Anders Stenberg
Jul 25, 2009·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Joseph BiedermanEric Mick
Jan 31, 2009·Drug and Alcohol Dependence·Denise B KandelChristine Schaffran
Jul 23, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Paolo CuratoloAugusto Pasini
Oct 11, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Edmund J S Sonuga-BarkeStephen V Faraone
Aug 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nanda N J RommelseJaap Oosterlaan
Dec 12, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Christian KielingLuis Augusto Rohde
Mar 5, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Ursula Pauli-PottKatja Becker
Dec 18, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Edmund J S Sonuga-Barke, Jeffrey M Halperin
Aug 25, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Joel NiggS Alexandra Burt
Oct 7, 2015·Frontiers in Psychiatry·Viviane SchuchMauro Muszkat
May 23, 2015·Development and Psychopathology·Sandra A WiebeLauren Wakschlag
Apr 9, 2015·European Child & Adolescent Psychiatry·Sarah HohmannTobias Banaschewski
Jun 25, 2013·Reproductive Toxicology·Alberto Mantovani, Aleksandra Fucic
Apr 11, 2009·Neuroscience·J B Savitz, W C Drevets
Mar 9, 2010·NeuroImage·Sarah Durston
Mar 2, 2010·Journal of Midwifery & Women's Health·Jane Blood-Siegfried, Elizabeth K Rende

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.