PMID: 9444328Jan 1, 1997Paper

Interaction of drugs for eradication therapy against antibiotic-resistant strains of Helicobacter pylori

Microbiology and Immunology
A GotohT Katsuyama

Abstract

To clarify the interactions of drugs for combination therapy of Helicobacter pylori infection, especially due to antibiotic-resistant strains, we have evaluated the in vitro effect of combining different drugs. Using a modified time-kill assay, we tested the effect of combining 2 drugs from 4 agents; amoxicillin (AMPC), clarithromycin (CAM), metronidazole (MTZ) and lansoprazole (a proton pump inhibitor). The H. pylori in the study consisted of 4 strains sensitive to the all drugs, 2 strains resistant only to CAM, 2 strains resistant only to MTZ, and 2 strains resistant to both CAM and MTZ. From the 6 different drug combinations, synergism was observed for 5 of the combinations, among which the combination of AMPC and CAM revealed such effects most frequently. However, all of the strains which showed synergism were sensitive to both of the drugs. In the case of the strains resistant to CAM and/or MTZ, no synergism was demonstrated in any of the combinations including CAM and/or MTZ. When a strain was resistant to one drug from a combination, no synergism was detected. Thus, the administration of a drug to which the strains are resistant may have no advantage in the eradication therapy of H. pylori. For a more effective and safer...Continue Reading

References

Jan 1, 1992·Antimicrobial Agents and Chemotherapy·H RautelinT U Kosunen
Mar 1, 1991·Journal of Gastroenterology and Hepatology·A T Axon
Dec 1, 1985·Antimicrobial Agents and Chemotherapy·C A McNultyR Wise
Nov 1, 1988·The Journal of Antimicrobial Chemotherapy·C A McNultyS P Wilkinson
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·T LambertP Courvalin
May 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M NakaoM Uekata
Dec 1, 1994·European Journal of Gastroenterology & Hepatology·H J O'Connor
Jan 19, 1995·The New England Journal of Medicine·J J SungA K Li
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·P Malfertheiner
Jul 1, 1993·Antimicrobial Agents and Chemotherapy·M P CooremanK J Hengels
Jul 1, 1993·Gastroenterology·D Y Graham, M F Go
May 1, 1993·Antimicrobial Agents and Chemotherapy·M J PavicićJ De Graaff

❮ Previous
Next ❯

Citations

Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Margareta SvenssonMikael Sörberg
Aug 15, 2006·International Journal of Medical Sciences·Yoshiyuki KawakamiKiyomi Kanaya
Oct 6, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Aristine ChengShan-Chwen Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.