PMID: 11342252May 9, 2001Paper

Interaction of enkephalin derivatives with reactive oxygen species

Biochimica Et Biophysica Acta
R CocciaM A Rosei

Abstract

The oxidation of opioid peptides by tyrosinase in the presence of an excess of a thiol gives rise to cysteinyldopa derivatives. The major products arising from the reaction between Leu-enkephalin and cysteine are represented by 5-S-cysteinyldopaenkephalin (5-CDenk) and 2-S-cysteinyldopaenkephalin (2-CDenk). The interaction of 5-CDenk and 2-CDenk with reactive oxygen species (ROS) has been studied. These compounds are able to scavenge superoxide anion, hydroxyl and peroxyl radicals as well as to reduce the lipid peroxidation rate induced by ABAP. The scavenging activities in all instances are dose-dependent. In some cases CDenks are more active than compounds recognized as strong radical scavengers, such as Trolox and mannitol. As a result of the action of the Fenton system, the CDenks (as well as the Enks) are oxidized into pigmented derivatives. The possible implications of the interaction of CDenks and Enks with ROS on melanization process in Parkinson's disease are discussed.

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Citations

May 30, 2002·Biochemical Pharmacology·Cesira FoppoliMaria Anna Rosei
Feb 12, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Pin GongRui Wang
Apr 30, 2009·Biomedical Chromatography : BMC·Hideaki IchibaTakeshi Fukushima
Jul 25, 2008·Biomedical Chromatography : BMC·Conceição FonsecaM Rosário M Domingues
Aug 5, 2005·Annual Review of Phytopathology·Jae-Hyuk Yu, Nancy Keller
Sep 21, 2006·Free Radical Research·Mario FontanaMaria Anna Rosei
Sep 25, 2012·The Journal of Physical Chemistry. B·Olivier MozziconacciChantal Houée-Levin

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