Interaction of ethanol with acetaminophen metabolism in the baboon

Biochemical Pharmacology
E AltomareC S Lieber

Abstract

To evaluate the effects of ethanol on acetaminophen metabolism and toxicity, twelve female baboons were studied using three experimental designs. In the first one, animals fed ethanol chronically and their pair-fed controls received acetaminophen intravenously (40 mg/kg), and drug metabolism was studied for 6 hr in blood and urine. Elimination of acetaminophen from plasma was accelerated significantly in baboons fed alcohol chronically, and urinary excretion of mercapturic acid conjugate was increased. In the second, the experiments were repeated with the addition of ethanol infusion (120-160 mg/kg/hr). During ethanol infusion, elimination of acetaminophen from plasma was still accelerated significantly in baboons fed alcohol chronically. In the third experimental design, four pairs of baboons fed an alcohol or an isocaloric control liquid diet received, in addition, acetaminophen (85 mg/kg/day) in their respective liquid diets for 2 weeks. Liver histology was studied before and after acetaminophen feeding; SGPT, SGOT, SGDH, acetaminophen blood levels and acetaminophen urinary metabolites were also assessed. No morphological or functional liver alterations were found after chronic acetaminophen treatment, and urinary excretion ...Continue Reading

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·C S Lieber
Apr 12, 2000·British Journal of Clinical Pharmacology·L F Prescott
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars E SchmidtHenrik Enghusen Poulsen
Jan 1, 1991·Drug and Alcohol Review·C S Lieber
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·C S Lieber
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·C GirreS Dally
Oct 16, 2015·British Journal of Clinical Pharmacology·Kelly L HaywardJennifer H Martin
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S Lieber
Nov 1, 1984·Alcoholism, Clinical and Experimental Research·B B MuhoberacS Schenker
Apr 25, 2016·Drug and Alcohol Dependence·Noah R GubnerMaciej L Goniewicz
Jan 1, 1987·Annals of the New York Academy of Sciences·C S LieberM A Leo
May 15, 2002·Addiction Biology·Stephen M Riordan, Roger Williams
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Schenker, W C Maddrey
Sep 1, 1996·Clinical Pharmacology and Therapeutics·J T SlatteryK E Thummel
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H J Zimmerman, W C Maddrey
Jul 26, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Nicholas A Buckley, Jayasri Srinivasan
Jan 1, 1990·Annals of Medicine·M J Mattila
Dec 1, 1991·Journal of the American College of Nutrition·C S Lieber
Dec 22, 1988·The New England Journal of Medicine·C S Lieber

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