PMID: 8944671Nov 1, 1996Paper

Interaction of exercise training and clenbuterol on GLUT-4 protein in muscle of obese Zucker rats

The American Journal of Physiology
C H KuoJ L Ivy

Abstract

Chronic administration of clenbuterol, a beta 2-adrenergic agonist, attenuates the exercise training-induced improvement in muscle insulin resistance of the obese Zucker rat. The present study was conducted to determine whether clenbuterol also attenuates the increase in muscle GLUT-4 protein that occurs with exercise training and whether the action of clenbuterol is related to its ability to downregulate the beta-adrenergic receptors. Female obese Zucker rats were randomly assigned to one of the following four groups: control (CON, n = 7), clenbuterol (CL, n = 8), exercise training (TR, n = 8), and clenbuterol with exercise training (CL+TR, n = 8). Rats assigned to the training groups were run on a rodent motor-driven treadmill for 6-7 wk. Rats receiving clenbuterol were intubated with 0.8 mg/kg body weight 30 min before running each day. Red quadriceps (RQ) and white quadriceps (WQ) GLUT-4 protein concentrations of TR rats were significantly greater than those of CON and CL+TR rats. The RQ GLUT-4 protein concentration of the CL+TR rats was significantly greater than that of CON rats, but this difference did not occur in the WQ. GLUT-4 protein concentrations were not different between the CON and CL rats. The patterns of RQ an...Continue Reading

References

May 1, 1991·Journal of Applied Physiology·E J HenriksenJ O Holloszy
Jun 1, 1989·Journal of Applied Physiology·J L IvyG M Kastello
May 1, 1986·Journal of Applied Physiology·D P Thomas, R R Jenkins
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·S IkemotoO Ezaki
Nov 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S L VoytikS F Konieczny

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Citations

Mar 20, 2001·American Journal of Physiology. Endocrinology and Metabolism·S J PanJ L Ivy
Nov 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daisuke HoshinoArend Bonen

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