Interaction of fat-stimulated gastric inhibitory polypeptide on pancreatic alpha and beta cell function

The Journal of Clinical Investigation
C A VerdonkF J Service

Abstract

Gastric inhibitory polypeptide (GIP) is considered to be the principal mediator of the enteroinsular axis. A glucose-insulin clamp technique was used to study the effects of differing blood glucose levels on the insulinotropic and glucagonotropic actions of fat-stimulated GIP in seven healthy subjects, as well as the effect of physiologic hyperinsulinemia on GIP secretion. Blood glucose levels were clamped for 4 h at 43+/-2 mg/dl (hypoglycemic clamp), 88+/-1 mg/dl (euglycemic clamp), and 141+/-2 mg/dl (hyperglycemic clamp) in the presence of a constant insulin infusion (100 m U/kg per h). Under hypoglycemic clamp conditions there was no increase in C-peptide nor glucagon after Lipomul ingestion, despite an increase of GIP of 51.7+/-8.7 ng/ml per 120 min. Under euglycemic clamp conditions, small and inconsistent increases in C-peptide and glucagon were observed after fat ingestion and a concomitant increase of GIP of 35.2+/-9.4 ng/ml per 120 min. Under hyperglycemic clamp conditions after fat ingestion and a GIP increase of 24.0+/-5.7 ng/ml per 120 min, C-peptide increased from 6.4+/-5 ng/ml to 11.0+/-1.1 ng/ml (P < 0.01) but glucagon did not change. These findings confirm that in healthy man GIP exerts its insulinotropic proper...Continue Reading

References

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Citations

Oct 1, 1984·Diabetologia·W Creutzfeldt
May 1, 1985·The Journal of Clinical Investigation·G BolliJ E Gerich
Jun 1, 1985·Archives internationales de physiologie et de biochimie·B Beck, C Villaume
Jun 5, 2012·Pharmacology & Therapeutics·Young Min ChoTimothy J Kieffer
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Feb 11, 2021·Diabetologia·Therese W FabriciusHypo-RESOLVE consortium

Related Concepts

Blood Glucose
C-Peptide
Ghee
Gastric Inhibitory Polypeptide
Enteric Hormones
Glucagon
Novolin
Islets of Langerhans

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