Interaction of flavin adenine dinucleotide (FAD) with a glassy carbon electrode surface

Chemistry & Biodiversity
Haizhen Wei, S Omanovic

Abstract

The interaction of flavin adenine dinucleotide (FAD) with a glassy carbon electrode (GCE) surface was investigated in terms of the FAD adsorption thermodynamics and kinetics, the subsequent electroreduction mechanism, and the corresponding electron-transfer rate. The kinetics of FAD electroreduction at the GCE was found to be an adsorption-controlled process. A set of electroreduction kinetic parameters was calculated: the true number of electrons involved in the FAD reduction, n=1.76, the apparent transfer coefficient, alpha(app)=0.41, and the apparent heterogeneous electron-transfer rate constant, k(app)=1.4 s(-1). The deviation of the number of exchanged electrons from the theoretical value for the complete reduction of FAD to FADH(2) (n=2) indicates that a small portion of FAD goes to a semiquinone state during the redox process. The FAD adsorption was well described by the Langmuir adsorption isotherm. The large negative apparent Gibbs energy of adsorption (DeltaG(ads)=-39.7 +/-0.4 kJ mol(-1)) indicated a highly spontaneous and strong adsorption of FAD on the GCE. The energetics of the adsorption process was found to be independent of the electrode surface charge in the electrochemical double-layer region. The kinetics of ...Continue Reading

References

Aug 31, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yuan-Di ZhaoQing-Ming Luo
Feb 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Alexis Damian, Sasha Omanovic

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Citations

Jul 24, 2010·Analytical and Bioanalytical Chemistry·Silvia CastrignanòGianfranco Gilardi
Apr 9, 2009·Bioelectrochemistry·Soren Demin, Elizabeth A H Hall
Mar 7, 2012·Journal of the American Chemical Society·Serena L J Tan, Richard D Webster
Oct 26, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Jacob M Goran, Keith J Stevenson
Oct 19, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kazuharu SugawaraAkira Kojima
Jun 1, 2016·Chemistry : a European Journal·Attila KormányosKrishnan Rajeshwar
Aug 28, 2021·Nanomaterials·Sónia O PereiraFlorinda M Costa

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