Interaction of Gold Nanorods with Human Dermal Fibroblasts: Cytotoxicity, Cellular Uptake, and Wound Healing.

Nanomaterials
Nouf N MahmoudRana Abu-Dahab

Abstract

Herein, the cytotoxicity, cellular uptake and wound healing of human dermal fibroblasts were investigated upon treatment with gold nanorods (GNR) decorated with different ligands. Neutral and cationic poly ethylene glycol (PEG)-decorated GNR demonstrated the least cytotoxicity and cellular internalization, while anionic- and bovine serum albumin (BSA)-coated GNR revealed significant cytotoxicity and cellular uptake into human dermal fibroblasts. The cell scratch test demonstrated that neutral, cationic PEGylated GNR and anionic-decorated GNR have accelerated the wound healing rate in vitro after 24 h of incubation with scratched human dermal fibroblasts compared to control, while there was a drastic retardation of wound healing rate of scratched fibroblasts upon exposure to BSA-GNR accompanied with a significant release of the inflammatory cytokine; interlukin-1β (IL-1β). The cytotoxicity of GNR against the dermal cells and their ability to enhance the wound healing in vitro are greatly linked to their surface modifications.

References

Dec 29, 2006·Small·Nadine PernodetMiriam Rafailovich
Apr 17, 2007·The Journal of Investigative Dermatology·Sabine WernerHans Smola
May 24, 2008·Colloids and Surfaces. B, Biointerfaces·Ganeshchandra SonavaneKimiko Makino
Aug 5, 2008·Molecular Pharmaceutics·Frank AlexisOmid C Farokhzad
Jul 2, 2010·Dermato-endocrinology·Marc SchneiderUlrich F Schaefer
Mar 17, 2011·ACS Nano·Christin GrabinskiSaber M Hussain
Sep 13, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Jyh-Gang LeuYao-Jen Liang
Dec 19, 2012·Toxicology Letters·Rosella CoradeghiniFrançois Rossi
Jan 9, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Onseok LeeSang Wook Son
Apr 4, 2013·Nano Letters·Xingchen YeChristopher B Murray
Apr 13, 2013·Current Opinion in Biotechnology·Larissa Y RizzoTwan Lammers
Aug 9, 2013·Journal of Wound Care·P Bainbridge
Nov 10, 2013·Seminars in Immunology·Patrizia Piccioli, Anna Rubartelli
Jul 18, 2014·Advances in Wound Care·Irena PastarMarjana Tomic-Canic
Jan 1, 2015·Beilstein Journal of Nanotechnology·Annika VogtJürgen Lademann
Jun 9, 2015·Journal of Biomedical Materials Research. Part a·Pelagie Marlene FaviThomas Jay Webster
Jun 20, 2015·Chemical Reviews·Yuanzeng MinAndrew Z Wang
Jan 21, 2016·Scientific Reports·Harold N McQuaidFred J Currell
Nov 20, 2016·Lasers in Surgery and Medicine·PikSuan LauGanesan Krishnan
Mar 21, 2017·Nanoscale Research Letters·Larissa Fernanda de Araújo VieiraMaria Danielma Dos Santos Reis
Jul 5, 2017·Chemical & Pharmaceutical Bulletin·Aung Thu Haine, Takuro Niidome
Jan 1, 2015·Nanobiomedicine·Veronika PivodováJitka Ulrichová
Jul 11, 2018·International Journal of Molecular Sciences·Priyanka SinghIvan Mijakovic

❮ Previous
Next ❯

Citations

Apr 15, 2020·Dose-response : a Publication of International Hormesis Society·Longqing Wang, Xiaofeng Sun
May 11, 2021·Frontiers in Pharmacology·Shengnan LiaoJinfeng Liao
May 30, 2021·Life Sciences·Abouzar BabaeiAfagh Moattari
Oct 14, 2021·ACS Applied Materials & Interfaces·Krishna R PulagamJordi Llop

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering
ELISA

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.