Interaction of guanidine-type surfactants with biological substances

Journal of Oleo Science
Miyuki MiyakeMasahiko Abe

Abstract

The interaction of guanidine-type cationic surfactants with bovine serum albumin (BSA) and liposome were investigated. Dodecylguanidine hydrochloride (C(12)A(0)G) and several dodecanoylamide alkylguanidine hydrochlorides (C(12)A(m)G, m = 2, 3, 4, 6) were used as the guanidine-type surfactants. In the interaction of these surfactants with BSA as a model protein, the binding isotherms of the surfactants to BSA were analysed. The structural change of the protein was also examined on the basis of circular dichroism and UV absobance data. In the interaction of these surfactants with liposome as a lipid bilayer model, we studied the effects of the surfactants on the solubilisation of liposomes and the release of carboxyfluorescein from liposomes. In addition, the effect of the surfactant molecular structure on the skin irritation was evaluated in connection with the interactions of the surfactants with BSA and liposome. It was found that small amounts of binding of C(12)A(0)G caused both a partial destruction of a-helix and an aggregation of BSA. C(12)A(0)G also induced the aggregation of liposomes, whereas C(12)A(m)G showed no such action. The presence of A(m) group in C(12)A(m)G appeared to reduce the skin irritation in parallel wi...Continue Reading

References

Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C Gloxhuber
Jul 17, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Miyuki MiyakeNobuo Oyama
Nov 8, 2008·Journal of Colloid and Interface Science·M Miyake, N Oyama

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Citations

Sep 20, 2012·Natural Product Reports·Roberto G S BerlinckMario F C Santos

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