Interaction of halothane with non-depolarizing neuromuscular blocking drugs in man

British Journal of Clinical Pharmacology
R Hughes, J P PAYNE


1 Tetanic and single twitch contractions of the adductor pollicis muscles, in response to indirect stimulation of each ulnar nerve, were recorded in patients anaesthetized with thiopentone and nitrous oxide in oxygen. 2 Concentrations of 1 and 2% halothane were administered for 10 min during recovery from neuromuscular paralysis by tubocurarine, dimethyl tubocurarine and gallamine. 3 During exposure to halothane, the peak contraction of the tetanic response was reduced and tetanic fade was increased whereas the single twitch was unaffected. 4 The effects of halothane on the tetanic responses were readily antagonized by intravenous neostigmine preceded by atropine. 5 Halothane could act post-synaptically by a non-depolarizing block or by desensitizing the post-synaptic receptors, but a pre-synaptic action seems more likely since neuromuscular block was only evident when tetanic stimulation was applied. Such an effect could be caused by impairment of the release of acetylcholine.


Jul 1, 1967·The Journal of Physiology·W D Paton, D R Waud
Jan 26, 1966·Annals of the New York Academy of Sciences·W F Riker, F G Standaert
Aug 1, 1968·British Journal of Anaesthesia·A Baraka
Jan 1, 1967·Anesthesiology·J H KarisW L Nastuk


Sep 30, 2000·Paediatric Anaesthesia·C Murphy, G Shorten
Aug 1, 1984·Journal of Pharmacological Methods·R Hughes
Mar 1, 1982·British Journal of Clinical Pharmacology·R HughesJ P PAYNE
Jun 1, 1981·British Journal of Clinical Pharmacology·J P PAYNE, R Hughes
Sep 1, 1986·Anaesthesia·J P PAYNE
Jul 23, 2008·BMC Clinical Pharmacology·John E MendelsonReese T Jones
Oct 27, 2017·Anesthesiology·Sorin J Brull, Mohamed Naguib

Related Concepts

Anesthesia Procedures
Atropine Sulfate Anhydrous
Neuromuscular Nondepolarizing Agents
Drug Interactions
Tubocurarine Chloride

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