PMID: 16519400Mar 8, 2006Paper

Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier, with human plasma: effects on coagulation, kallikrein-kinin, and complement systems

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Hideki AbeHideyoshi Harashima

Abstract

Hemoglobin vesicles (HbVs), cellular-type artificial oxygen carriers containing human hemoglobin, were assessed for their biocompatibility by mixing with human plasma in vitro. Among three kinds of HbVs (PEG-DPEA-HbV, PEG-DPPG-HbV and DPPG-HbV), PEG-DPEA-HbV did not affect the extrinsic or intrinsic coagulation activities of the plasma, while PEG-DPPG-HbV and DPPG-HbV tended to shorten the intrinsic coagulation time. The kallikrein-kinin cascade of the plasma was slightly activated by PEG-DPPG-HbV and DPPG-HbV, but not by PEG-DPEA-HbV. The complement consumption of the plasma was observed by incubation with DPPG-HbV, but not with PEG-DPEA-HbV or PEG-DPPG-HbV. These results indicate that PEG-DPEA-HbV has a higher biocompatibility with human plasma.

References

Apr 13, 1992·Biochimica Et Biophysica Acta·M C WoodleD Papahadjopoulos
Apr 1, 1984·Biochemical Society Transactions·C R Alving
Sep 3, 1994·Lancet·R B LaingA J Steers
Apr 20, 1994·Biochimica Et Biophysica Acta·D V DevineP R Cullis
Jul 1, 1997·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K KobayashiE Tsuchida
Sep 15, 1998·Archives of Biochemistry and Biophysics·A J BradleyD E Brooks
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J SzebeniC R Alving
Nov 18, 2000·Progress in Lipid Research·O C BoermanG Storm
Jan 6, 2001·Journal of Drug Targeting·A H BrouwersF H Corstens
May 19, 2001·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·S WakamotoK Ikebuchi
Nov 16, 2001·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·H AbeH Ikeda
Jan 16, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·P LavermanG Storm

❮ Previous
Next ❯

Citations

Jan 26, 2011·Chemistry and Physics of Lipids·Keitaro Sou
Feb 12, 2011·Macromolecular Bioscience·Taihang LiYubin Huang
May 23, 2012·Journal of Biomedical Materials Research. Part a·Hiromi SakaiMayumi Kano
Nov 17, 2009·Methods in Enzymology·Hiromi SakaiEishun Tsuchida
Nov 21, 2007·Journal of Liposome Research·Hiromi Sakai, Eishun Tsuchida
Nov 29, 2007·Journal of Internal Medicine·H SakaiE Tsuchida
Nov 6, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Thomas W Stief
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Hideki AbeEishun Tsuchida
Apr 15, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kazuaki TaguchiMasaki Otagiri
Jan 8, 2011·The Journal of Pharmacology and Experimental Therapeutics·Daisuke TakahashiHisami Ikeda
Feb 23, 2008·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·C Robert Valeri, Gina Ragno
Jan 14, 2011·The Journal of Pharmacology and Experimental Therapeutics·Kazuaki TaguchiMasaki Otagiri
Feb 12, 2009·Bioconjugate Chemistry·Eishun TsuchidaKoichi Kobayashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.