Abstract
Hemoglobin vesicles (HbVs), cellular-type artificial oxygen carriers containing human hemoglobin, were assessed for their biocompatibility by mixing with human plasma in vitro. Among three kinds of HbVs (PEG-DPEA-HbV, PEG-DPPG-HbV and DPPG-HbV), PEG-DPEA-HbV did not affect the extrinsic or intrinsic coagulation activities of the plasma, while PEG-DPPG-HbV and DPPG-HbV tended to shorten the intrinsic coagulation time. The kallikrein-kinin cascade of the plasma was slightly activated by PEG-DPPG-HbV and DPPG-HbV, but not by PEG-DPEA-HbV. The complement consumption of the plasma was observed by incubation with DPPG-HbV, but not with PEG-DPEA-HbV or PEG-DPPG-HbV. These results indicate that PEG-DPEA-HbV has a higher biocompatibility with human plasma.
References
Apr 13, 1992·Biochimica Et Biophysica Acta·M C WoodleD Papahadjopoulos
Jul 30, 1990·FEBS Letters·A L KlibanovL Huang
Jul 16, 1985·Biochemistry·M A GriepG L Nelsestuen
Apr 1, 1984·Biochemical Society Transactions·C R Alving
Sep 3, 1994·Lancet·R B LaingA J Steers
Oct 22, 1994·Lancet·O RingdénJ Tollemar
Nov 30, 1994·Biochemical and Biophysical Research Communications·J SzebeniC R Alving
Apr 20, 1994·Biochimica Et Biophysica Acta·D V DevineP R Cullis
Dec 4, 1996·Biochimica Et Biophysica Acta·J SzebeniC R Alving
Jan 1, 1997·Bioconjugate Chemistry·H SakaiE Tsuchida
Jul 1, 1997·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K KobayashiE Tsuchida
May 22, 1998·Transfusion·H AbeS Sekiguchi
Sep 15, 1998·Archives of Biochemistry and Biophysics·A J BradleyD E Brooks
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J SzebeniC R Alving
Nov 18, 2000·Progress in Lipid Research·O C BoermanG Storm
Jan 6, 2001·Journal of Drug Targeting·A H BrouwersF H Corstens
May 19, 2001·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·S WakamotoK Ikebuchi
Nov 16, 2001·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·H AbeH Ikeda
Jan 16, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·P LavermanG Storm
Jan 25, 2002·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·T ItoK Ikebuchi
Oct 4, 2003·Biotechnology Progress·Keitaro SouEishun Tsuchida
Citations
Aug 28, 2010·Journal of Pharmaceutical Sciences·Kazuaki TaguchiMasaki Otagiri
Jan 26, 2011·Chemistry and Physics of Lipids·Keitaro Sou
Aug 17, 2010·Toxicology and Applied Pharmacology·Kazuaki TaguchiMasaki Otagiri
Oct 2, 2015·Biological & Pharmaceutical Bulletin·Kazuaki TaguchiMasaki Otagiri
Feb 8, 2008·Journal of Biomedical Materials Research. Part a·Miki YamaguchiHisami Ikeda
Feb 12, 2011·Macromolecular Bioscience·Taihang LiYubin Huang
May 23, 2012·Journal of Biomedical Materials Research. Part a·Hiromi SakaiMayumi Kano
May 1, 2012·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Ozlem ColakFatma Arslan
Feb 5, 2008·Biochimica Et Biophysica Acta·Keitaro Sou, Eishun Tsuchida
Nov 17, 2009·Methods in Enzymology·Hiromi SakaiEishun Tsuchida
Mar 16, 2017·Journal of Functional Biomaterials·Hiromi Sakai
Nov 21, 2007·Journal of Liposome Research·Hiromi Sakai, Eishun Tsuchida
Nov 29, 2007·Journal of Internal Medicine·H SakaiE Tsuchida
Nov 6, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Thomas W Stief
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Hideki AbeEishun Tsuchida
Apr 15, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kazuaki TaguchiMasaki Otagiri
Jan 8, 2011·The Journal of Pharmacology and Experimental Therapeutics·Daisuke TakahashiHisami Ikeda
Feb 23, 2008·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·C Robert Valeri, Gina Ragno
Jan 14, 2011·The Journal of Pharmacology and Experimental Therapeutics·Kazuaki TaguchiMasaki Otagiri
Feb 12, 2009·Bioconjugate Chemistry·Eishun TsuchidaKoichi Kobayashi