Interaction of herpes simplex virus type 2 (HSV-2) glycoprotein D with the host cell surface is sufficient to induce Chlamydia trachomatis persistence.

Microbiology
Jennifer VanoverR V Schoborg

Abstract

When presented with certain unfavourable environmental conditions, Chlamydia trachomatis reticulate bodies (RBs) enter into a viable, yet non-cultivable state called persistence. Previously, we established an in vitro C. trachomatis and herpes simplex virus type 2 (HSV-2) co-infection model. These data indicate that (i) viral co-infection stimulates chlamydial persistence, (ii) productive HSV replication is not required for persistence induction, and (iii) HSV-induced persistence is not mediated by any currently characterized anti-chlamydial pathway or persistence inducer. In this study we demonstrated that chlamydial infectivity, though initially suppressed, recovered within 44 h of co-infection with UV-inactivated HSV-2, demonstrating that HSV-induced persistence is reversible. Co-incubation of chemically fixed, HSV-2-infected inducer cells with viable, C. trachomatis-infected responder cells both suppressed production of infectious chlamydial progeny and stimulated formation of swollen, aberrantly shaped RBs. In addition, pre-incubation of viral particles with viral glycoprotein D (gD)-specific neutralizing antibody prevented co-infection-induced persistence. Finally, exposure of C. trachomatis-infected cells to a soluble, r...Continue Reading

References

Jan 1, 1977·The Journal of Antimicrobial Chemotherapy·F W Johnson, D Hobson
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A O Fuller, P G Spear
Jul 1, 1994·American Journal of Obstetrics and Gynecology·D L PattonC C Kuo
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W L BeattyR P Morrison
May 23, 1997·The Journal of Biological Chemistry·H HsuW J Boyle
Aug 19, 2000·The Journal of Infectious Diseases·D DeanW E Stamm
Jan 5, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·E Y BraginaG A Dmitriev
May 16, 2002·The Journal of Biological Chemistry·Christine Fehlner-GardinerGrant McClarty
Jun 6, 2003·Cytokine & Growth Factor Reviews·Steve W Granger, Sandra Rickert
Oct 22, 2003·The Journal of Cell Biology·Natalia CheshenkoBetsy C Herold
Dec 19, 2003·The New England Journal of Medicine·Jeffrey F Peipert
Dec 23, 2003·Journal of Biochemistry·Kazuya Shimizu, Yoshimi Takai
Mar 25, 2004·Infection and Immunity·Richard J HoganPeter Timms
Apr 2, 2004·Cellular Microbiology·Patricia G Spear
Nov 24, 2004·Biological Chemistry·Hiroyuki Nakanishi, Yoshimi Takai
Dec 18, 2004·The Journal of General Virology·Christopher ParryHelena Browne
Jul 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·David E NelsonHarlan D Caldwell
Jul 27, 2005·FEMS Microbiology Reviews·Yasser M Abdelrahman, Robert J Belland
Feb 14, 2006·Methods in Enzymology·Hisakazu Ogita, Yoshimi Takai
Nov 14, 2006·The Journal of General Virology·Sven HoppeDagmar Knebel-Mörsdorf
Apr 5, 2007·Annals of the New York Academy of Sciences·M Teresa SciortinoAntonio Mastino
Aug 30, 2008·Biochemical Pharmacology·Maria Teresa SciortinoAntonio Mastino

❮ Previous
Next ❯

Citations

Apr 5, 2011·Microbes and Infection·R V Schoborg
Feb 15, 2011·Microbes and Infection·Andrew BroadbentMyra McClure
Jul 30, 2015·BMC Infectious Diseases·Fabian Yuh Shiong Kong, Jane Simone Hocking
May 31, 2014·International Journal of Medical Microbiology : IJMM·Paola MastromarinoRosa Sessa
Nov 22, 2014·Frontiers in Cellular and Infection Microbiology·Jennifer V HallRobert V Schoborg
Mar 25, 2014·Frontiers in Cellular and Infection Microbiology·Robert V Schoborg, Nicole Borel
Aug 18, 2012·PloS One·Valerie Le Sage, Bruce W Banfield
Jan 13, 2018·Frontiers in Cellular and Infection Microbiology·Jennifer KintnerJennifer V Hall
Jan 9, 2019·Frontiers in Microbiology·Maria Emilia PanzettaHector Alex Saka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.