Interaction of herpes simplex virus with mononuclear phagocytes is dependent on the differentiation stage of the cells

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
T BruunM Degré

Abstract

The interaction of herpes simplex virus (HSV) with mononuclear phagocytes (MP), i.e. monocytes and macrophages, is of importance for the pathogenesis of HSV infections. MP are known to play a significant role in the cellular defence against infections with HSV, but it has also been shown that HSV-1 affects MP. The infection of these cells at different stages of differentiation has different outcomes, and may result in the alteration of important cellular functions. HSV-1 inhibits the morphological differentiation of human monocytes, and this inhibition occurs in spite of the fact that human monocytes are non-permissive to HSV-1. We have studied the effect of HSV infection of monocytes and macrophages on production of essential cytokines and related this effect to the reproduction of the virus. Blood-derived MP were cultured in vitro and inoculated with HSV at different stages of differentiation. Replication of the virus was measured by infectivity titration, detection of HSV antigens by immunofluorescence and detection of HSV-specific mRNA. In monocytes, no viral replication and no production of late protein was seen. HSV IE gene was transcribed in monocytes from some donors, but not from others. In macrophages, virus replicate...Continue Reading

References

Jan 1, 1992·Chemical Immunology·C A Dinarello
Sep 1, 1989·Immunology Today·F R Balkwill, F Burke
Sep 1, 1982·Infection and Immunity·B SvennerholmE Lycke
Mar 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F Belardelli
Jan 1, 1994·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J M Cavaillon
Sep 1, 1994·The Journal of Infectious Diseases·E AureliusO Strannegård

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Citations

Mar 3, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T BruunM Degré
Nov 9, 2002·The Journal of Infectious Diseases·James R LokensgardPhillip K Peterson

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